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Overweight older adults, particularly after an injury, are at high risk for accelerated knee osteoarthritis: data from the Osteoarthritis Initiative

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Abstract

We explored whether age and body mass index (BMI) can help identify a subset of individuals who are at high risk for accelerated knee osteoarthritis (AKOA) compared with common knee osteoarthritis (KOA). In the Osteoarthritis Initiative, a multicenter observational cohort study of KOA (n = 4796), we studied participants without KOA at baseline (Kellgren-Lawrence (KL) <2). Participants could have one of three outcomes: (1) AKOA, ≥1 knee progressed to end-stage KOA within 48 months; (2) common KOA, ≥1 knee increased in radiographic scoring within 48 months (excluding those with AKOA); and (3) no KOA, no change in KL grade in either knee. After verifying an interaction between age, BMI, and recent knee injury, we determined if we could identify a specific subset of individuals at high risk for AKOA instead of KOA. First, we reviewed three-dimensional graphs with age, BMI, and probability of AKOA versus KOA on the axes. We then conducted a logistic regression with AKOA as the outcome and age-BMI groups as the predictor. In our main analyses, we found that older individuals with a BMI <35 kg/m2 were more likely to develop AKOA than common KOA (n = 64; mean [SD] BMI = 27.3 [3.1] kg/m2; odds ratio = 3.47, 95 % confidence interval = 1.70 to 7.10), especially if they had a recent knee injury. While older age and greater BMI are independently associated with AKOA, we found that older individuals who had a higher BMI, particularly if they have an injury, were more likely to develop AKOA than common KOA.

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References

  1. Driban JB, Eaton CB, Lo GH, Ward RJ, Lu B, McAlindon TE (2014) Association of knee injuries with accelerated knee osteoarthritis progression: data from the Osteoarthritis Initiative. Arthritis Care Res 66:1673–1679. doi:10.1002/acr.22359

    Article  Google Scholar 

  2. Driban JB, Price LL, Eaton CB, Lu B, Lo GH, Lapane KL, McAlindon TE (2015) Individuals with incident accelerated knee osteoarthritis have greater pain than those with common knee osteoarthritis progression: data from the Osteoarthritis Initiative. Clin Rheumatol. doi:10.1007/s10067-015-3128-2

  3. Peterfy CG, Schneider E, Nevitt M (2008) The osteoarthritis initiative: report on the design rationale for the magnetic resonance imaging protocol for the knee. Osteoarthritis Cartilage 16:1433–1441. doi:10.1016/j.joca.2008.06.016

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. The Osteoarthritis Initiative. http://oai.epi-ucsf.org/. Accessed 08 December 2015

  5. Ferrandiz ML, Terencio MC, Ruhi R, Verges J, Montell E, Torrent A, Alcaraz MJ (2014) Influence of age on osteoarthritis progression after anterior cruciate ligament transection in rats. Exp Gerontol 55:44–48. doi:10.1016/j.exger.2014.03.010

    Article  PubMed  Google Scholar 

  6. Wu CL, Jain D, McNeill JN, Little D, Anderson JA, Huebner JL, Kraus VB, Rodriguiz RM, Wetsel WC, Guilak F (2014) Dietary fatty acid content regulates wound repair and the pathogenesis of osteoarthritis following joint injury. Ann Rheum Dis. doi:10.1136/annrheumdis-2014-205601

  7. Mooney RA, Sampson ER, Lerea J, Rosier RN, Zuscik MJ (2011) High-fat diet accelerates progression of osteoarthritis after meniscal/ligamentous injury. Arthritis Res Ther 13:R198. doi:10.1186/ar3529

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Driban JB, Barr AE, Amin M, Sitler MR, Barbe MF (2011) Joint inflammation and early degeneration induced by high force reaching are attenuated by ibuprofen in an animal model of work-related musculoskeletal disorder. J Biomed Biotechnol 2011:691412

    Article  PubMed  PubMed Central  Google Scholar 

  9. Kerkhof HJ, Bierma-Zeinstra SM, Castano-Betancourt MC, de Maat MP, Hofman A, Pols HA, Rivadeneira F, Witteman JC, Uitterlinden AG, van Meurs JB (2010) Serum C reactive protein levels and genetic variation in the CRP gene are not associated with the prevalence, incidence or progression of osteoarthritis independent of body mass index. Ann Rheum Dis 69:1976–1982. doi:10.1136/ard.2009.125260

    Article  PubMed  Google Scholar 

  10. Lucey AJ, Paschos GK, Thorsdottir I, Martinez JA, Cashman KD, Kiely M (2013) Young overweight and obese women with lower circulating osteocalcin concentrations exhibit higher insulin resistance and concentrations of C-reactive protein. Nutr Res 33:67–75. doi:10.1016/j.nutres.2012.11.011

    Article  CAS  PubMed  Google Scholar 

  11. Labouesse MA, Gertz ER, Piccolo BD, Souza EC, Schuster GU, Witbracht MG, Woodhouse LR, Adams SH, Keim NL, Van Loan MD (2014) Associations among endocrine, inflammatory, and bone markers, body composition and weight loss induced bone loss. Bone 64:138–146. doi:10.1016/j.bone.2014.03.047

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Jonsson H, Helgadottir GP, Aspelund T, Eiriksdottir G, Sigurdsson S, Siggeirsdottir K, Ingvarsson T, Harris TB, Launer L, Gudnason V (2011) Hand osteoarthritis severity is associated with total knee joint replacements independently of BMI. The Ages-Reykjavik Study. Open Rheumatol J 5:7–12. doi:10.2174/1874312901105010007

    Article  PubMed  PubMed Central  Google Scholar 

  13. Kraus VB, Stabler TV, Luta G, Renner JB, Dragomir AD, Jordan JM (2007) Interpretation of serum C-reactive protein (CRP) levels for cardiovascular disease risk is complicated by race, pulmonary disease, body mass index, gender, and osteoarthritis. Osteoarthritis Cartilage 15:966–971. doi:10.1016/j.joca.2007.02.014

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Chen HC, Shah S, Stabler TV, Li YJ, Kraus VB (2008) Biomarkers associated with clinical phenotypes of hand osteoarthritis in a large multigenerational family: the CARRIAGE family study. Osteoarthritis Cartilage 16:1054–1059. doi:10.1016/j.joca.2007.12.010

    Article  PubMed  PubMed Central  Google Scholar 

  15. Lee SW, Jo HH, Kim MR, You YO, Kim JH (2012) Association between obesity, metabolic risks and serum osteocalcin level in postmenopausal women. Gynecol Endocrinol 28:472–477. doi:10.3109/09513590.2011.633660

    Article  CAS  PubMed  Google Scholar 

  16. Rosa SC, Rufino AT, Judas FM, Tenreiro CM, Lopes MC, Mendes AF (2011) Role of glucose as a modulator of anabolic and catabolic gene expression in normal and osteoarthritic human chondrocytes. J Cell Biochem 112:2813–2824. doi:10.1002/jcb.23196

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

These analyses were funded by the National Institutes of Health (HHSN268201200032C, Eaton & R01-AR065977-01A1, Driban). The Osteoarthritis Initiative is a public-private partnership comprised of five contracts (N01-AR-2-2258; N01-AR-2-2259; N01-AR-2-2260; N01-AR-2-2261; N01-AR-2-2262) funded by the National Institutes of Health, a branch of the Department of Health and Human Services, and conducted by the OAI Study Investigators. Private funding partners include Merck Research Laboratories; Novartis Pharmaceuticals Corporation, GlaxoSmithKline; and Pfizer, Inc. Private sector funding for the OAI is managed by the Foundation for the National Institutes of Health. This manuscript was prepared using an OAI public use dataset and does not necessarily reflect the opinions or views of the OAI investigators, the NIH, or the private funding partners.

This work was also supported in part by the Houston Veterans Affairs Health Services Research and Development Center of Excellence (HFP90-020). The views expressed in this article are those of the author(s) and do not necessarily represent the views of the Department of Veterans Affairs.

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Authors and Affiliations

  1. Division of Rheumatology, Tufts Medical Center, 800 Washington Street, Box #406, Boston, MA, 02111, USA

    Jeffrey B. Driban & Timothy E. McAlindon

  2. Center for Primary Care and Prevention, Alpert Medical School of Brown University, 111 Brewster Street, Pawtucket, RI, 02860, USA

    Charles B. Eaton

  3. Medical Care Line and Research Care Line, Houston Health Services Research and Development (HSR&D) Center of Excellence Michael E. DeBakey VAMC, Houston, TX, USA

    Grace H. Lo

  4. Section of Immunology, Allergy, and Rheumatology, Baylor College of Medicine, 1 Baylor Plaza, BCM-285, Houston, TX, 77030, USA

    Grace H. Lo

  5. The Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, 02111, USA

    Lori Lyn Price

  6. Tufts Clinical and Translational Science Institute, Tufts University, 800 Washington Street, Box #63, Boston, MA, 02111, USA

    Lori Lyn Price

  7. Brigham & Women’s Hospital and Harvard Medical School, 75 Francis Street PBB-B3, Boston, MA, 02115, USA

    Bing Lu

  8. Department of Anatomy and Cell Biology, Temple University School of Medicine, 3500 North Broad Street, Philadelphia, PA, 19140, USA

    Mary F. Barbe

Authors
  1. Jeffrey B. Driban
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  2. Charles B. Eaton
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  3. Grace H. Lo
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  4. Lori Lyn Price
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  5. Bing Lu
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  6. Mary F. Barbe
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  7. Timothy E. McAlindon
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Corresponding author

Correspondence to Jeffrey B. Driban.

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Ethical standards

Institutional review boards at each OAI clinical site and the OAI coordinating center (University of California, San Francisco) approved the OAI study and all participants provided informed consent prior to participating in the OAI.

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Driban, J.B., Eaton, C.B., Lo, G.H. et al. Overweight older adults, particularly after an injury, are at high risk for accelerated knee osteoarthritis: data from the Osteoarthritis Initiative. Clin Rheumatol 35, 1071–1076 (2016). https://doi.org/10.1007/s10067-015-3152-2

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  • DOI: https://doi.org/10.1007/s10067-015-3152-2

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