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Complement in antineutrophil cytoplasmic antibody-associated vasculitis

  • Review Article
  • The Asia Pacific Meeting of Vasculitis and ANCA Workshop 2012
  • Published:
Clinical and Experimental Nephrology Aims and scope Submit manuscript

Abstract

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a group of autoimmune disorders. It was previously assumed that the complement system is not involved in the development of ANCA-associated vasculitis due to its “pauci-immune” feature in renal histology. However, increasing evidence indicates that activation of the complement system, especially via the alternative complement pathway, plays a crucial role in the pathogenesis of ANCA-associated vasculitis. In this brief review, we discuss the evidence, including in vivo, in vitro, and clinical studies, for complement system activation in ANCA-associated vasculitis.

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Acknowledgments

This study is supported by a grant from the Chinese 973 project (no. 2012CB517702), “National Key Technology Research and Development (R&D) Program” of the Ministry of Science and Technology of China (no. 2011BAI10B04), and two grants from the National Natural Science Fund (nos. 30972733 and 81021004).

Conflict of interest

None.

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Authors and Affiliations

  1. Renal Division, Department of Medicine, Peking University First Hospital, 100034, Beijing, China

    Jun Yuan, Min Chen & Ming-Hui Zhao

  2. Institute of Nephrology, Peking University, 100034, Beijing, China

    Jun Yuan, Min Chen & Ming-Hui Zhao

  3. Key Laboratory of Renal Disease, Ministry of Health of China, 100034, Beijing, China

    Jun Yuan, Min Chen & Ming-Hui Zhao

  4. Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, 100034, Beijing, China

    Jun Yuan, Min Chen & Ming-Hui Zhao

  5. Peking-Tsinghua Center for Life Sciences, 100034, Beijing, China

    Jun Yuan, Min Chen & Ming-Hui Zhao

  6. Hubei University of Traditional Chinese Medicine, Wuchang, 430061, Wuhan, China

    Jun Yuan

  7. Hubei Hospital of Traditional Chinese Medicine, Wuchang, 430061, Wuhan, China

    Jun Yuan

Authors
  1. Jun Yuan
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  2. Min Chen
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  3. Ming-Hui Zhao
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Corresponding author

Correspondence to Min Chen.

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Yuan, J., Chen, M. & Zhao, MH. Complement in antineutrophil cytoplasmic antibody-associated vasculitis. Clin Exp Nephrol 17, 642–645 (2013). https://doi.org/10.1007/s10157-012-0700-9

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  • DOI: https://doi.org/10.1007/s10157-012-0700-9

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