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A functional polymorphism, rs28493229, in ITPKC and risk of Kawasaki disease: an integrated meta-analysis

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Abstract

Kawasaki disease (KD) is a multi-systemic vasculitis which preferentially affects infants and children. A single nucleotide polymorphism (rs28493229) in the inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) was identified to be associated with the increased risk of KD; however, in more recent studies associations have been controversial. Thus, we performed a meta-analysis, integrating case–control and transmission/disequilibrium test (TDT) studies, to investigate the relationship between this polymorphism and risk of KD. A total of ten case–control and two TDT studies, comprising 3,821 cases, 12,802 controls and 949 families, were included in this meta-analysis. There was a significant association between the C allele of rs28493229 and the increased risk of KD (OR = 1.53, 95 % CI = 1.34−1.74, P < 0.001), by the random-effects model because of heterogeneity (Q = 27.67, P heterogeneity = 0.004). Nevertheless, it was screened out by meta-regression analysis that the coronary artery lesions (CALs) status of KD could partly explain the heterogeneity, with consistently significant associations in both subgroups after stratification by CALs status. Moreover, estimates before and after the deletion of each study were similar in sensitivity analysis, indicating robust stability of the meta-analysis. This meta-analysis reveals that the functional polymorphism rs28493229 in ITPKC significantly contributes to the risk of KD.

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Acknowledgments

This work was supported by the Fundamental Research Funds for the Central Universities (HUST: Nos. 2011TS019 and 2010QN005) and Science Technology Department of Zhejiang Province (2011C23085).

Conflict of interest

The authors have declared no conflict of interest.

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Authors and Affiliations

  1. Department of Epidemiology and Biostatistics and MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Jiao Lou, Li Zou, Rong Zhong, Ti Zhang, Yu Sun, Xuzai Lu, Guanglian Xiong & Jing Wu

  2. Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

    Sanqing Xu

  3. Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China

    Li Liu

  4. School of Medicine and Health Management, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

    Chuanqi Li

  5. Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China

    Li Wang

  6. Department of Cardiology, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China

    Wei Wang & Fangqi Gong

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  1. Jiao Lou
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  2. Sanqing Xu
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  6. Yu Sun
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Correspondence to Jing Wu.

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Lou, J., Xu, S., Zou, L. et al. A functional polymorphism, rs28493229, in ITPKC and risk of Kawasaki disease: an integrated meta-analysis. Mol Biol Rep 39, 11137–11144 (2012). https://doi.org/10.1007/s11033-012-2022-0

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  • DOI: https://doi.org/10.1007/s11033-012-2022-0

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