Skip to main content

Advertisement

Log in

Primate spondyloarthropathy

  • Published:
Current Rheumatology Reports Aims and scope Submit manuscript

Abstract

Spondyloarthropathy is a common occurrence in Old World primates, with only limited presence in New World monkeys. Clearly distinguished from rheumatoid arthritis, this erosive arthritis afflicts 20% of great apes, baboons, and rhesus macaques and had been increasing in frequency. Habitatdependent infectious agent diarrhea-induced reactive arthritis is implicated on a background of genetic predisposition. A gorilla-derived therapeutic preventative approach has possible application in human clinical medicine.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References and Recommended Reading

  1. Rothschild BM: Origin of spondyloarthropathy in the jurassic. Lancet 2002, 360:1454.

    Article  PubMed  Google Scholar 

  2. Rothschild BM, Sebes JI, Rothschild C: Antiquity of arthritis: spondyloarthropathy identified in the paleocene of north america. Clin Exp Rheumatol 1998, 16:573–575.

    PubMed  CAS  Google Scholar 

  3. Rothschild BM, Prothero DR, Rothschild C: Origins of spondyloarthropathy in perissodactyla. Clin Exp Rheumatol 2001, 19:628–632. Documents increase in frequency of spondyloarthropathy through geologic time in horses and rhinoceris.

    PubMed  CAS  Google Scholar 

  4. Rothschild BM, Martin LD: Paleopathology: Disease in the Fossil Record. London: CRC Press; 1993.

    Google Scholar 

  5. Rothschild BM, Martin LD: Skeletal impact of disease. Bull New Mexico Mus Natl Hist 2005, In press. Critical human data-based population approach to diagnosis of diseases impacting the skeleton, providing fossil and contemporary frequencies of disease across the zoologic spectrum.

  6. Martin R, Selim J: Man of apes resets clock of evolution. Discover 2004, 25:20–21.

    Google Scholar 

  7. Rothschild BM, Woods RJ: Spondyloarthropathy: erosive arthritis in representative defleshed bones. Am J Phys Anthropol 1991, 85:125–134. Clearly reveals character of spondyloarthropathy in defleshed bones, as a population phenomenon.

    Article  PubMed  CAS  Google Scholar 

  8. Trtkova K, Mayer WE, O’Huigin C, et al.: Mhc-DRB genes and the origin of new world monkeys. Mol Phylogenet Evol 1995, 4:408–419.

    Article  PubMed  CAS  Google Scholar 

  9. Rothschild BM, Rothschild C: Epidemic of spondyloarthropathy in baboons. J Med Primatol 1996, 25:69–70. Documents increase in frequency of spondyloarthropathy in both wild-caught and captive baboons over the past 80 years.

    PubMed  CAS  Google Scholar 

  10. Rothschild BM: Arthritis in callithrix jacchus: calcium pyrophosphate deposition disease and spondyloarthropathy. J Med Primatol 1993, 22:313–316.

    PubMed  CAS  Google Scholar 

  11. Rothschild BM, Rothschild C: No laughing matter: spondyloarthropathy in hyaenidae. J Zoo Wildl Med 1994, 25:259–263.

    Google Scholar 

  12. Rothschild BM, Rothschild C: Trans-mammalian pandemic of inflammatory arthritis (spondyloarthropathy variety): persistence since the pleistocene. Paleontologic Society Publ 1996, 8:330.

    Google Scholar 

  13. Rothschild BM, Woods RJ: Spondyloarthropathy in gorillas. Semin Arthritis Rheum 1989, 18:267–276. Appearance and population characteristics of arthritis in gorilla is classic for psoriatic arthritis.

    Article  PubMed  CAS  Google Scholar 

  14. Rothschild BM, Woods RJ: Spondyloarthropathy as an old world phenomenon. Semin Arthritis Rheum 1992, 21:306–316.

    Article  PubMed  CAS  Google Scholar 

  15. Rothschild BM, Woods RJ: Erosive arthritis and spondyloarthropathy in old world primates. Am J Phys Anthropol 1992, 88:389–400.

    Article  PubMed  CAS  Google Scholar 

  16. Rothschild BM, Wang X-M, Cifelli R: Spondyloarthropathy in ursidae: a sexually transmitted disease? Natl Geogr Res 1993, 9:382–284.

    Google Scholar 

  17. Rothschild BM, Woods RJ, Rothschild C: Paradox of erosive arthritis in new world monkeys: collagen-induced versus naturally occurring spondyloarthropathy. Clin Exp Rheumatol 1994, 10:92–93. Naturally occuring arthritis in 20% of rhesus macaques is classic for human spondyloarthropathy. The collagen-induced arthritis model is compared with rheumatoid arthritis and spondyloarthropathy and matches neither.

    Google Scholar 

  18. Rothschild BM, Wang X-M, Shoshani J: Spondyloarthropathy in proboscideans. J Zoo Wildl Med 1994, 25:360–366.

    Google Scholar 

  19. Rothschild BM, Hong N, Turnquist JE: Naturally occurring spondyloarthropathy in cayo santiago rhesus macaques. Clin Exp Rheumatol 1997, 15:45–51. Naturally occuring arthritis in 20% of rhesus macaques is classic for human spondyloarthropathy. The collagen-induced arthritis model is compared with rheumatoid arthritis and spondyloarthropathy and matches neither.

    PubMed  CAS  Google Scholar 

  20. Rothschild BM, Rothschild C, Woods RJ: Inflammatory arthritis in large cats: an expanded spectrum of spondyloarthropathy. J Zoo Wildl Med 1998, 29:279–284.

    PubMed  CAS  Google Scholar 

  21. Rothschild BM, Rothschild C, Woods JR: Inflammatory arthritis in canids: spondyloarthropathy. J Zoo Wildl Med 2000, 32:58–64.

    Google Scholar 

  22. McEwen C, DiTata D, Lingg C, et al.: Ankylosing spondylitis and spondylitis accompanying ulcerative colitis, regional enteritis, psoriasis, and Reiter’s disease: a comparative study. Arthritis Rheum 1971, 14:291–318.

    Article  PubMed  CAS  Google Scholar 

  23. Resnick D: Diagnosis of Bone and Joint Disorders. 2nd edition. Philadelphia: W.B. Saunders; 2002.

    Google Scholar 

  24. Rothschild BM, van Woods RJ: Reactive erosive arthritis in chimpanzees. Am J Primatol 1991, 25:49–56.

    Article  Google Scholar 

  25. Rothschild BM, Woods RJ: Arthritis in new world monkeys: osteoarthritis, calcium pyrophosphate deposition disease, and spondyloarthropathy. Int J Primatol 1993, 14:61–78.

    Article  Google Scholar 

  26. Cathcart JE, Hayes KC, Gonnerman WA, et al.: Experimental arthritis in a nonhuman primate. I. Induction by bovine type II collagen. Lab Invest 1986, 54:26–31.

    PubMed  CAS  Google Scholar 

  27. Renlund RC, Pritzker KP, Cheng P-T, et al.: Rhesus monkeys (macaca mulatta) as a model for calcium pyrophosphate dihydrate crystal deposition disease. J Med Primatol 1986, l5:ll-l6.

    Google Scholar 

  28. Rothschild BM, Woods RJ: Osteoarthritis, calcium pyrophosphate deposition disease, and osseous infection in old world monkeys and prosimians. Am J Phys Anthropol 1992, 87:341–347.

    Article  PubMed  CAS  Google Scholar 

  29. Chapman WL Jr, Crowell WA: Amyloidosis in rhesus monkeys with rheumatoid arthritis and enterocolitis. J Am Vet Med Assoc 1977, 171:855–858.

    PubMed  Google Scholar 

  30. Ford E, Hird D, Franti C, et al.: Analysis of factors associated with sixty cases of chronic arthritis in Rhesus monkeys at the california primate research center. Lab Anim Sci 1986, 89:561.

    Google Scholar 

  31. Rothschild BM, Rothschild C: Nineteenth century spondyloarthropathy independent of socioeconomic status: lack of skeletal collection bias. J Rheumatol 1993, 20:314–319.

    PubMed  CAS  Google Scholar 

  32. Rogers J, Waldron T, Dieppe P, Watt I: Arthropathies in palaeopathology: the basis of classification according to most probable cause. J Archaeol Sci 1987, 14:179–193.

    Article  Google Scholar 

  33. Kilgore L: Possible case of rheumatoid arthritis from Sudanese Nubia. Am J Phys Anthropol 1989, 79:177–183.

    Article  PubMed  CAS  Google Scholar 

  34. Rothschild BM, Arriaza B, Woods RJ, et al.: Spondyloarthropathy identified as the etiology of nubian erosive arthritis. Am J Phys Anthropol 1999, 109:259–267.

    Article  PubMed  CAS  Google Scholar 

  35. Anderson ST, Schiller CA: Rheumatoid-like arthritis in a lion tailed macaque. J Rheumatol 1991, 18:1247–1250.

    PubMed  CAS  Google Scholar 

  36. Rothschild BM: Rheumatoid arthritis at a time of passage. J Rheumatol 2001, 28:245–250.

    PubMed  CAS  Google Scholar 

  37. Jayo MJ, Zanolli MD, Jayo JM: Psoriatic plaques in macaca fasicularis. Vet Pathol 1988, 25:282–285.

    PubMed  CAS  Google Scholar 

  38. Wallace MR, Garst PD, Papadimos TJ, et al.: The return of acute rheumatic fever in young adults. JAMA 1989, 262:2557–2561.

    Article  PubMed  CAS  Google Scholar 

  39. Smuts BB, Cheney DL, Seyfarth RM, et al.: Primate Societies. Chicago: University of Chicago Press; 1986.

    Google Scholar 

  40. Napier JR, Napier PH: A Handbook of Living Primates: Morphology, Ecology and Behavior of Non-human Primates. New York: Academic Press; 1967.

    Google Scholar 

  41. Cadavid LF, Watkins DI: MHC class I genes in nonhuman primates. In Molecular Biology and Evolution of Blood Groups and MHC Antigens in Primates. Edited by Blancher A, Klein J WW. Berlin: Springer; 1997:339–357.

    Google Scholar 

  42. Bontrop RE: MHC genes, immune response and vaccines. In Molecular Biology and Evolution of Blood Groups and MHC Antigens in Primates. Edited by Blancher A, Klein J, Socha WW. Berlin: Springer; 1997:449–463.

    Google Scholar 

  43. Rothschild BM, Ruhli FJ: Paniscus, troglodytes troglodytes and troglodytes sartyus, arthritis of a different pan. Am J Primatol 2005; In press. Important documentation of habitat/bacterial contamination in denouement of spondyloarthropathy.

  44. Rothschild BM, Ruhli FJ: Comparison of arthritis characteristics in lowland gorilla and mountain gorilla beringei. Amer J Primatol 2005; In press. Important documentation of habitat/bacterial contamination in denouement of spondyloarthropathy.

  45. Neiffer DL, Rothschild BM, Marks SK, et al.: Management of reactive arthritis in a juvenile gorilla (gorilla gorilla gorilla) with long-term sulfasalazine therapy. J Zoo Wildl Med 2000, 31:539–551. Diagnosis and preventative treatment of gorilla with spondyloarthropathy.

    PubMed  CAS  Google Scholar 

  46. Inman RD, Johnston ME, Hodge M, et al.: Postdysenteric reactive arthritis: a clinical and immunogenetic study following an outbreak of salmonellosis. Arthritis Rheum 1988, 31:1377–1383.

    Article  PubMed  CAS  Google Scholar 

  47. Klumpp SA, Weaver DS, Jerome CP, et al.: Salmonella osteomyelitis in a rhesus monkey. Vet Pathol 1986, 23:190–197.

    Article  PubMed  CAS  Google Scholar 

  48. Brancker WM: Primates. In Manual of Exotic Pets. Edited by Cooper JE, Hutchison MF, Jackson OF, Julian E. Cheltenham: British Small Animal Veterinary Association; 1985:99–105.

    Google Scholar 

  49. Watkins DI, Chen ZW, Hughes AL, et al.: Evolution of the MHC class I genes of a new world primate from ancestral. Nature 1990, 346:60–63.

    Article  PubMed  CAS  Google Scholar 

  50. Hazuda DJ, Young SD, Guare JP, et al.: Integrase inhibitors and cellular immunity suppress retroviral replication in rhesus macaques. Science 2004, 305:528–532.

    Article  PubMed  CAS  Google Scholar 

  51. Tehranzazdeh J, Ter-Oganesyan RR, Steinbach LS: Musculoskeletal disorders associated with HIV infection and AIDS. Part II: non-infectious musculoskeletal conditions. Skeletal Radiol 2004, 33:311–320.

    Article  Google Scholar 

  52. Restrepo CS, Lemos DF, Gordillo H: Image findings in musculoskeletal complications of AIDS. Radiology 2004, 24:1029–1051.

    Google Scholar 

  53. Boyson JE, McAdam SN, Gallimore A, et al.: The MHC E locus in macaques is polymorphic and is conserved between macaques and humans. Immunogenetics 1995, 41:59–68.

    Article  PubMed  CAS  Google Scholar 

  54. Boyson JE, Shufflebotham C, Cadavid LF, et al.: The MHC class I genes of the rhesus monkey: different evolutionary histories of MHC class I and II genes in primates. J Immunol 1996, 156:4656–4665.

    PubMed  CAS  Google Scholar 

  55. van Erp SH, Dixon B, Figueroa F, et al.: Identification and characterisation of a new major histocompatibility complex class I gene in carp (Cyprinus carpio L). Immunogenetics 1996, 44:49–61.

    Article  PubMed  Google Scholar 

  56. Dixon B, van Erp SH, Rodrigues PN, et al.: Fish major histocompatibility complex genes: an expansion. Dev Comp Immunol 1995, 19:109–133.

    Article  PubMed  CAS  Google Scholar 

  57. Otting N, Bontrop N: Characterization of the rhesus macaque (Macaca mulatta) equivalent of HLA-F. Immunogenetics 1993, 38:141–145.

    Article  PubMed  CAS  Google Scholar 

  58. Urvater JA, Hickman H, Dzuris JL, et al.: Gorillas with spondyloarthropathies express an MHC class I molecule with only limited sequence similarity to HLA-B27 that binds peptides with arginine at P2. J Immunol 2001, 166:3334–3344. Human leukocyte antigens issues in gorillas with similarities to Human B27, but ubiquitous.

    PubMed  CAS  Google Scholar 

  59. Coquillard G, Lau M, Kletzel M, et al.: Identification of tow pseudogenes with sequence homology to human and gorilla MHC class IA genes: ancestral haplotype in the filipino population. Human Immunol 2004, 65:665–673.

    Article  CAS  Google Scholar 

  60. Lawlor DA, Ward FE, Ennis PD, et al.: HLA-A and B polymorphisms predate the divergence of humans and chimpanzees. Nature 1988, 335:268–271.

    Article  PubMed  CAS  Google Scholar 

  61. Satta Y, Mayer WE, Klein J: Evolutionary relationship of HLA-DRB genes inferred from intron sequences. J Mol Evol 1996, 42:648–657.

    Article  PubMed  CAS  Google Scholar 

  62. Bakker NP, van Erck MG, Otting N, et al.: Resistance to collagen-induced arthritis in a nonhuman primate species maps to the major histocompatibility complex class I region. J Exp Med 1992, 175:933–937.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rothschild, B.M. Primate spondyloarthropathy. Curr Rheumatol Rep 7, 173–181 (2005). https://doi.org/10.1007/s11926-996-0036-0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11926-996-0036-0

Keywords

Navigation