Abstract
There are conflicting reports as to the association between serum level of magnesium (Mg) and postmenopausal osteoporosis (OP). The purpose of the present study is to clarify the association between serum level of Mg and postmenopausal OP using a meta-analysis approach. We searched articles indexed in Pubmed and the Chinese Journal Full-text Database (CJFD) published as of October 2013 that met our predefined criteria. Seven eligible studies involving 1,349 postmenopausal women from 12 case-control study arms were identified. Overall, pooled analysis indicated that postmenopausal osteoporotic women had a lower serum level of Mg than the healthy controls (standardized mean difference [SMD] = −0.55, 95 % confidence interval [CI] = −0.83 to −0.26). Further subgroup analysis found a similar pattern in Turkey (SMD = −0.66, 95 % CI = −0.99 to −0.32) and Belgium (SMD = −0.98, 95 % CI = −1.91 to −0.05), but not in China (SMD = 0.02, 95 % CI = −0.21 to 0.26). And the difference of serum level of Mg between postmenopausal osteoporotic women and healthy controls below the age of 60 years (SMD = −0.61, 95 % CI = −1.09 to −0.13) was similar to that among the population over 60 years (SMD = −0.49, 95 % CI = −0.80 to −0.18).In conclusion, this meta-analysis suggests that the low serum level of Mg seems to be a risk factor for OP among the postmenopausal women. However, the subgroup analysis found that there was contradiction regarding races and geography, like China and Turkey. Thus, this finding needs further confirmation by trans-regional multicenter study to obtain better understanding of causal relationships between serum Mg and postmenopausal OP.
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References
Castiglioni S, Cazzaniga A, Albisetti W, Maier JA (2013) Magnesium and osteoporosis: current state of knowledge and future research directions. Nutrients 5:3022–3033
Rachner TD, Khosla S, Hofbauer LC (2011) Osteoporosis: now and the future. Lancet 377:1276–1287
Rude RK, Gruber HE (2004) Magnesium deficiency and osteoporosis: animal and human observations. J Nutr Biochem 15:710–716
Belluci MM, Schoenmaker T, Rossa-Junior C, Orrico SR, de Vries TJ et al (2013) Magnesium deficiency results in an increased formation of osteoclasts. J Nutr Biochem 24:1488–1498
Yamaguchi M (2010) Role of nutritional zinc in the prevention of osteoporosis. Mol Cell Biochem 338:241–254
Gulekli B, Davies MC, Jacobs HS (1994) Effect of treatment on established osteoporosis in young women with amenorrhoea. Clin Endocrinol (Oxf) 41:275–281
Reginster JY, Strause L, Deroisy R, Lecart MP, Saltman P et al (1989) Preliminary report of decreased serum magnesium in postmenopausal osteoporosis. Magnesium 8:106–109
Okyay E, Ertugrul C, Acar B, Sisman AR, Onvural B et al (2013) Comparative evaluation of serum levels of main minerals and postmenopausal osteoporosis. Maturitas 76:320–325
Gur A, Colpan L, Nas K, Cevik R, Sarac J et al (2002) The role of trace minerals in the pathogenesis of postmenopausal osteoporosis and a new effect of calcitonin. J Bone Miner Metab 20:39–43
Mutlu M, Argun M, Kilic E, Saraymen R, Yazar S (2007) Magnesium, zinc and copper status in osteoporotic, osteopenic and normal post-menopausal women. J Int Med Res 35:692–695
Nieves JW (2013) Skeletal effects of nutrients and nutraceuticals, beyond calcium and vitamin D. Osteoporos Int 24:771–786
Navarro-Gonzalez JF, Mora-Fernandez C, Garcia-Perez J (2009) Clinical implications of disordered magnesium homeostasis in chronic renal failure and dialysis. Semin Dial 22:37–44
Liu SZ, Yan H, Xu P, Li JP, Zhuang GH et al (2009) Correlation analysis between bone mineral density and serum element contents of postmenopausal women in Xi'an urban area. Biol Trace Elem Res 131:205–214
Haliloglu B, Aksungar FB, Ilter E, Peker H, Akin FT et al (2010) Relationship between bone mineral density, bone turnover markers and homocysteine, folate and vitamin B12 levels in postmenopausal women. Arch Gynecol Obstet 281:663–668
Jinyu C, Zhengyan S, Li Y, Lin C (2007) The relationship between serum magnesium level and bone mineral density in postmenopausal Chinese women. Chin J Osteoporos 13:837–839
Cohen L, Kitzes R (1981) Infrared spectroscopy and magnesium content of bone mineral in osteoporotic women. Isr J Med Sci 17:1123–1125
Burnell JM, Liu C, Miller AG, Teubner E (1986) Effects of dietary alteration of bicarbonate and magnesium on rat bone. Am J Physiol 250:F302–F307
Stendig-Lindberg G, Tepper R, Leichter I (1993) Trabecular bone density in a two year controlled trial of peroral magnesium in osteoporosis. Magnes Res 6:155–163
Sahota O, Mundey MK, San P, Godber IM, Hosking DJ (2006) Vitamin D insufficiency and the blunted PTH response in established osteoporosis: the role of magnesium deficiency. Osteoporos Int 17:1013–1021
Kimble RB, Srivastava S, Ross FP, Matayoshi A, Pacifici R (1996) Estrogen deficiency increases the ability of stromal cells to support murine osteoclastogenesis via an interleukin-1 and tumor necrosis factor-mediated stimulation of macrophage colony-stimulating factor production. J Biol Chem 271:28890–28897
Rude RK, Gruber HE, Norton HJ, Wei LY, Frausto A et al (2004) Bone loss induced by dietary magnesium reduction to 10 % of the nutrient requirement in rats is associated with increased release of substance P and tumor necrosis factor-alpha. J Nutr 134:79–85
Rude RK, Gruber HE, Wei LY, Frausto A, Mills BG (2003) Magnesium deficiency: effect on bone and mineral metabolism in the mouse. Calcif Tissue Int 72:32–41
Leidi M, Dellera F, Mariotti M, Banfi G, Crapanzano C et al (2012) Nitric oxide mediates low magnesium inhibition of osteoblast-like cell proliferation. J Nutr Biochem 23:1224–1229
Carpenter TO, Mackowiak SJ, Troiano N, Gundberg CM (1992) Osteocalcin and its message: relationship to bone histology in magnesium-deprived rats. Am J Physiol 263:E107–E114
Creedon A, Flynn A, Cashman K (1999) The effect of moderately and severely restricted dietary magnesium intakes on bone composition and bone metabolism in the rat. Br J Nutr 82:63–71
Lai CC, Singer L, Armstrong WD (1975) Bone composition and phosphatase activity in magnesium deficiency in rats. J Bone Joint Surg Am 57:516–522
He Q, Xia Y, Raymond HF, Peng R, Yang F et al (2011) HIV trends and related risk factors among men having sex with men in mainland China: findings from a systematic literature review. Southeast Asian J Trop Med Public Health 42:616–633
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The project was supported by the Guangzhou Municipal Science and Technology Project (11C32060748) and the National Natural Science Foundation of China (81100728).
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Zheng, J., Mao, X., Ling, J. et al. Association Between Serum Level of Magnesium and Postmenopausal Osteoporosis: A Meta-analysis. Biol Trace Elem Res 159, 8–14 (2014). https://doi.org/10.1007/s12011-014-9961-3
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DOI: https://doi.org/10.1007/s12011-014-9961-3