Abstract
RECENT work has shown that the presence of dextran decreases the solubility of macromolecules, such as proteins1. Since the relative decrease in solubility is a function of both protein size and polysaccharide concentration, the phenomenon can be interpreted as a steric exclusion of protein from a portion of the solvent within the domain of the polysaccharide chains. If this is the primary mechanism, then low-molecular-weight substances should be similarly effected provided that the polysaccharide concentration is sufficiently high.
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LAURENT, T. Solubility of Sodium Urate in the Presence of Chondroitin-4-sulphate. Nature 202, 1334 (1964). https://doi.org/10.1038/2021334a0
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DOI: https://doi.org/10.1038/2021334a0
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