MicroRNA-140 and the silencing of osteoarthritis
- Endocrine Unit, Massachusetts General Hospital-Harvard Medical School, Boston, Massachusetts 02114, USA
Abstract
MicroRNAs (miRNAs) have emerged as important modulators in development, tissue homeostasis, and diseases. In this issue of Genes & Development, Miyaki and colleagues (pp. 1173–1185) report that miR-140 is involved in the pathogenesis of osteoarthritis by regulating, at least in part, ADAMTS5. Moreover, mice lacking miR-140 are dwarf as a consequence of impaired chondrocyte proliferation. This study is the first in vivo demonstration that miR-140 has a critical and nonredundant role in cartilage development and homeostasis.
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↵1 Corresponding author.
E-MAIL schipani{at}helix.mgh.harvard.edu; FAX (617) 724-7543.
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Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.1939310.
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