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Gout and crystal arthropathies

medwireNews editor's pick

Allopurinol does not increase CKD risk in patients with gout


Allopurinol, given at a starting dose of at least 300 mg/day, does not increase the risk for chronic kidney disease stage 3 or higher, and may in fact reduce it, in patients with newly diagnosed gout, study data show.

medwireNews editor's pick

IL-1 beta inhibition reduces gout attack risk

Antibodies (illustration)

Administration of canakinumab, an interleukin-1β inhibitor, every 3 months is associated with a significantly reduced risk for gout, without lowering serum uric acid levels, shows a secondary exploratory analysis of the CANTOS trial.

Journal article

Calcium crystal deposition diseases: Beyond gout

Features of calcium crystal deposition disease on imaging

In this review, the main clinical manifestations of calcium pyrophosphate dihydrate and basic calcium phosphate crystal deposition are discussed, along with the biological effects of these crystals, current therapeutic approaches and future directions in therapy [read more].
McCarthy GM, Dunne A. Nat Rev Rheumatol 2018. doi: 10.1038/s41584-018-0078-5

Journal article

Goals of gout treatment: A patient perspective

Doctor and male patient (symbolic image with models)

The primary objective of this study was to perform formative work to understand and define gout treatment goals from a patient perspective, using the nominal group technique [read more].
Singh JA. Clin Rheumatol 2018; 37: 2557–2566. doi: 10.1007/s10067-018-4243-7

Journal article

Obesity, hypertension and diuretic use as risk factors for incident gout: A systematic review and meta-analysis of cohort studies

Pills, stethoscope, and tape measure

The aim of this systematic review and meta-analysis was to assess the risk of incident gout associated with obesity, hypertension and diuretic use [read more].
Evans PL et al. Arthritis Res Ther 2018; 20: 136. doi: 10.1186/s13075-018-1612-1

21-02-2018 | Gout | Editorial | Article

Gout therapies and cardiovascular risk

Editorial Board member Fernando Pérez-Ruiz highlights recent clinical trials evaluating the effect of febuxostat on risk of cardiovascular comorbidities, and discusses alternative treatments for gout patients with cardiovascular disease.

30-10-2017 | Gout | Editorial | Article

Evolution or revolution in urate-lowering therapies for gout?

Editorial Board member Fernando Pérez-Ruiz reflects on changing concepts in the understanding of gout, and reviews the latest developments in new urate-lowering medications for the management of gout.

18-07-2017 | Gout | Editorial | Article

The future of gout: Are you ready for it?

Editorial Board member Fernando Pérez-Ruiz discusses the recent increase in gout-related hospitalizations and asks if we are ready for a future of clinical inertia and passivity when it comes to the management of gout.

Themed collections

30-10-2017 | Gout | Themed collection | Collection

Urate-lowering therapies in gout

This content collection provides an overview of the pathogenesis of gout, followed by a review of current urate-lowering therapies, with an emphasis on their comparative safety and efficacy.

Journal articles and book chapters

30-08-2018 | Gout | Article

The risk of gout among patients with sleep apnea: A matched cohort study

Blagojevic-Bucknall M et al. Arthritis Rheumatol 2018. doi: 10.1002/art.40662

20-08-2018 | Gout | Article

Gout and hearing impairment in the elderly: A retrospective cohort study using the US Medicare claims data

Singh JA, Cleveland JD. BMJ Open 2018; 8: e022854. doi: 10.1136/bmjopen-2018-022854

14-08-2018 | Gout | Article

Integrated safety studies of the urate reabsorption inhibitor lesinurad in treatment of gout

Terkeltaub R et al. Rheumatology (Oxford) 2018: key245. doi: 10.1093/rheumatology/key245


A convenient single access point, providing rheumatology professionals with links to a comprehensive set of clinical practice guidelines from a wide range of relevant organizations.

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Themed collections

Compendia of selected, recently published, free full-text journal and book content from Springer Nature and other publishers on a particular topic within rheumatology management, as recommended by our Editorial Board.

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