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Gout and crystal arthropathies

Journal article

Obesity, hypertension and diuretic use as risk factors for incident gout: A systematic review and meta-analysis of cohort studies

Pills, stethoscope, and tape measure

The aim of this systematic review and meta-analysis was to assess the risk of incident gout associated with obesity, hypertension and diuretic use [read more].
Evans PL et al. Arthritis Res Ther 2018; 20: 136. doi: 10.1186/s13075-018-1612-1

Journal article

Predicting response or non-response to urate-lowering therapy in patients with gout

Gout in foot (symbolic image with model)

The authors review the extent of treatment success or failure with the xanthine oxidoreductase inhibitors allopurinol and febuxostat and indicate how the dosage of urate-lowering therapy may be modified to increase the response in the majority of patients with gout [read more].
Graham GG et al. Curr Rheumatol Rep 2018; 20: 47. doi: 10.1007/s11926-018-0760-2

Expert Opinion: Editorial

Audits on gout management: Far from excellence, but working on it

Doctor auditing medication (symbolic image with model)

Editorial Board member Fernando Pérez-Ruiz analyzes recent audits on the management of gout in primary and secondary care, and suggests strategies to improve clinical practice [read more].

medwireNews editor's pick

‘Reassuring’ findings on fracture risk in patients with gout

Doctor holding spinal x-ray (symbolic image with model)

Results of a large observational study suggest that patients with gout do not have an elevated risk for fragility fractures.

medwireNews editor's pick

Verinurad–febuxostat combination shows promise for the treatment of gout

Gout in foot (symbolic image with model)

Results of a phase IIa trial support further investigation of the selective URAT1 inhibitor verinurad in combination with febuxostat for the treatment of gout.

21-02-2018 | Gout | Editorial | Article

Gout therapies and cardiovascular risk

Editorial Board member Fernando Pérez-Ruiz highlights recent clinical trials evaluating the effect of febuxostat on risk of cardiovascular comorbidities, and discusses alternative treatments for gout patients with cardiovascular disease.

30-10-2017 | Gout | Editorial | Article

Evolution or revolution in urate-lowering therapies for gout?

Editorial Board member Fernando Pérez-Ruiz reflects on changing concepts in the understanding of gout, and reviews the latest developments in new urate-lowering medications for the management of gout.

18-07-2017 | Gout | Editorial | Article

The future of gout: Are you ready for it?

Editorial Board member Fernando Pérez-Ruiz discusses the recent increase in gout-related hospitalizations and asks if we are ready for a future of clinical inertia and passivity when it comes to the management of gout.

Themed collections

30-10-2017 | Gout | Themed collection | Collection

Urate-lowering therapies in gout

This content collection provides an overview of the pathogenesis of gout, followed by a review of current urate-lowering therapies, with an emphasis on their comparative safety and efficacy.

Journal articles and book chapters

15-07-2018 | Gout | Article

Gout and the risk of incident erectile dysfunction: A body mass index-matched population-based study

Schlesinger N, Lu N, Choi K. J Rheumatol 2018. doi: 10.3899/jrheum.170444

11-07-2018 | Gout | Article

Gout prevalence and predictors of urate-lowering therapy use: Results from a population-based study

Pisaniello HL et al. Arthritis Res Ther 2018; 20: 143. doi: 10.1186/s13075-018-1633-9

06-07-2018 | Gout | Article

Next-generation sequencing profiling of mitochondrial genomes in gout

Tseng CC et al. Arthritis Res Ther 2018; 20: 137. doi: 10.1186/s13075-018-1637-5

05-07-2018 | Gout | Article

Mediation analysis to understand genetic relationships between habitual coffee intake and gout

Hutton J et al. Arthritis Res Ther 2018; 20: 135. doi: 10.1186/s13075-018-1629-5


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