4. Treatment of Hyperuricemia in Gout
Authors: Fernando Perez-Ruiz, Ana Maria Herrero-Beites
Publisher: Springer Healthcare Ltd.
The treatment of gout with chronic clinical manifestations comprises three aspects, in the following order of clinical importance: (1) reducing serum urate to the therapeutic range to dissolve monosodium urate crystals (MSUCs) formed in tissues, using urate-lowering therapy (ULT); (2) preventing or reducing the risk of episodes of acute inflammation (EAIs) that appear and even increase in frequency during the initiation of ULT (prophylaxis); (3) promptly, safely, and effectively treating any EAIs that may appear until proper and stable serum urate levels are achieved.