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01-01-2015 | Osteoarthritis | Book Chapter | Article

13. Precision Medicine for Osteoarthritis

Authors: MD, MSc, FRCSC Christian J. H. Veillette, PhD Igor Jurisica

Publisher: Springer International Publishing

Abstract

1.
Precision medicine, or what patients and the media often call personalized medicine, aims to utilize molecular profiles of patient biospecimens and increasingly precise outcome metrics from diverse biosensors to more accurately diagnose a disease, tailor the therapy a patient receives, and monitor response.
 
2.
In order to accomplish the goals of precision medicine in osteoarthritis, several key components of biomedical research (target identification, marker identification, molecular mechanisms) and clinical medicine (treatment, diagnosis, health outcomes) must be seamlessly integrated across several data repositories (clinical records, biospecimen, -omics databases) and analyzed using integrative data mining and iterative learning strategies.
 
3.
A clinically meaningful and feasible strategy is required for identifying OA phenotypes for targeted treatment.
 
4.
The OA Data Integration Platform (OADIP) provides comprehensive, expert curated clinical and molecular data repository across OA. Advances in molecular profiling, interoperability, integration, and exchange of data combined with machine learning techniques will enable comprehensive signatures for OA subtypes to be identified and targeted for treatment and discovery.
 
5.
The feasibility and reality of precision medicine for OA are on the horizon as we strive to provide the right care to the right patient at the right time.
 

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