Osteoarthritis

Metformin use is associated with a significant reduction in the risk for total knee or hip replacement among people with type 2 diabetes, shows research published in CMAJ.

A diet and exercise program delivered in community settings may improve some clinical outcomes for people with knee osteoarthritis and overweight or obesity, suggest findings from the WE-CAN pragmatic randomized controlled trial.

Early trial results suggest that ultrasound-guided genicular nerve block may represent a promising short-term treatment option for pain associated with knee osteoarthritis.

The PARTNER model of primary care delivery for patients with knee osteoarthritis may improve knee pain and function over that achieved by general practitioner care alone, say Australian researchers.

Recurrent intra-articular corticosteroid injections are often inferior to other injectables, including placebo, for the long-term improvement of pain, function, and quality of life in people with osteoarthritis, meta-analysis data suggest.

Individuals with rheumatic conditions living in areas with the highest social and heat vulnerability are significantly more likely to experience recurrent hospitalizations than those living in the least vulnerable areas, research suggests.

People with knee osteoarthritis may experience modest improvements in physical function while following a 12-week self-guided online yoga program, but the benefits are not sustained when the exercise is stopped, researchers report.

A reduction in BMI is associated with a lower risk for onset and progression of the structural defects of knee osteoarthritis, indicate findings from a multicohort study.

Intra-articular injection with botulinum toxin A results in clinically meaningful pain reduction for up to 3 months in people with base-of-thumb osteoarthritis, French study findings indicate.

Findings from a systematic review and meta-analysis indicate that viscosupplementation does not significantly improve pain and physical function in people with knee osteoarthritis, but increases the risk for serious adverse events.

Results from a post-hoc analysis suggest that increased dietary vitamin K intake is associated with greater improvement in symptoms among patients with knee osteoarthritis, warranting further examination in clinical trials.

Findings from an observational study suggest that walking for exercise is associated with a reduced risk for developing frequent knee pain among people aged 50 years and older with knee osteoarthritis.

The tumor necrosis factor inhibitor adalimumab does not improve pain or function in people with knee osteoarthritis, indicate phase 2 trial results.

Polygenic risk scores for advanced knee and hip osteoarthritis are significantly associated with the likelihood of requiring joint replacement in community-dwelling older adults, Australian study findings indicate.