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03-01-2016 | Psoriatic arthritis | Book Chapter | Article

Pathogenesis of psoriasis and psoriatic arthritis

Authors:
Laura Coates, Laura Savage, Paul Emery

Abstract

The pathophysiology of psoriasis is multifaceted and dynamic, involving a complex interplay between constitutive cells of the skin and the innate and adaptive immune systems. Until the early 1980s, psoriasis was considered to be primarily a disease of epidermal keratinocyte proliferation, with the cutaneous inflammatory infiltrate a secondary consequence.

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