Medicine Matters rheumatology

Autoantigen

Aminoacyl t-RNA synthetase

Prevalence (%)

Clinical Characteristics

Jo-1

Histidyl

25

Myositis more common and severe, Mechanic’s hand

PL-7

Threonyl

<5

ILD dominant, mild or no muscle weakness

PL-12

Alanyl

<5

EJ

Glycyl

<2

Rare and poorly defined; overall all non-Jo-1 ASS have more severe ILD*

OJ

Isoleucyl

<2

KS

Asparaginyl

<2

Zo

Phenyl Alanyl

<1

Ha

Tyrosyl

<1