Early trial results suggest that ultrasound-guided genicular nerve block may represent a promising short-term treatment option for pain associated with knee osteoarthritis.

Pain intensity strongly correlates with disease activity measured by DAS28-ESR in people with rheumatoid arthritis, with the association mostly explained by the patient global assessment element of the composite score, study data show.

The PARTNER model of primary care delivery for patients with knee osteoarthritis may improve knee pain and function over that achieved by general practitioner care alone, say Australian researchers.

Risk stratification in the primary care setting may not lead to significant improvements in pain or function for people with musculoskeletal disorders, but may have benefits for clinical decision-making, the UK-based STarT MSK trial shows.

Intra-articular injection with botulinum toxin A results in clinically meaningful pain reduction for up to 3 months in people with base-of-thumb osteoarthritis, French study findings indicate.

Nearly all patients with myositis report current or past pain, which is often treated with opioids, shows a survey by the patient-led advocacy organization Myositis Support and Understanding.

Intramuscular glucocorticoid injection is noninferior to intra-articular injection for reducing knee pain after 8 and 24 weeks in patients with knee osteoarthritis, but may be inferior at 4 weeks, research shows.

Higher BMI is associated with increased hand pain in people with hand osteoarthritis, which researchers suggest could be partly mediated by increased leptin levels.

Classifying individuals with musculoskeletal symptoms and no clinical synovitis using anti-cyclic citrullinated peptide antibody levels and self-reported hand or foot pain may be useful to prioritize rheumatology referrals, study findings indicate.

Pain affects almost nine in every 10 people with systemic sclerosis, with multiple disease-related factors potentially contributing to pain intensity, researchers report.

Overweight or obese people with knee osteoarthritis may benefit from a diet- and exercise-focused telehealth intervention, which researchers have shown can improve pain and function over 6 months.

Symmetrical- and small-joint pain may be associated with an increased risk for developing rheumatoid arthritis among family members of those with the condition, suggest findings from the PREVeNT-RA study.

Study findings suggest that approximately one-third of patients with rheumatoid arthritis have long-term unacceptable pain, despite control of inflammation in the majority of these people.

A web-based exercise intervention combined with text messaging support for people with knee osteoarthritis leads to greater improvements in pain and function at 6 months than web-based information alone, Australian research shows.

Twelve weeks of high-dose vitamin D supplementation does not improve pain levels for women with fibromyalgia, research suggests.

Serotonin–noradrenaline reuptake inhibitors may reduce pain for up to 3 months in people with osteoarthritis, but it is unclear whether the effect is clinically relevant, show the results of a meta-analysis published in The BMJ .

Researchers have found that adolescents with chronic musculoskeletal pain, particularly those with gastrointestinal problems, may be at risk for disordered eating.

Denis Poddubnyy reports on the spinal pain improvements seen with secukinumab in patients with axial spondyloarthritis, including the benefit of up-titration for suboptimal responders (5:16).