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31-05-2014 | Osteoporosis | Review | Article

Novel Assessment Tools for Osteoporosis Diagnosis and Treatment

Current Osteoporosis Reports

Authors: Bo Gong, Gurjit S. Mandair, Felix W. Wehrli, Michael D. Morris

Publisher: Springer US


This review describes new technologies for the diagnosis and treatment, including fracture risk prediction, of postmenopausal osteoporosis. Four promising technologies and their potential for clinical translation and basic science studies are discussed. These include reference point indentation (RPI), Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, and magnetic resonance imaging (MRI). While each modality exploits different physical principles, the commonality is that none of them require use of ionizing radiation. To provide context for the new developments, brief summaries are provided for the current state of biomarker assays, fracture risk assessment (FRAX), and other fracture risk prediction algorithms and quantitative ultrasound (QUS) measurements.

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