Pathophysiology

Baglivo and Ribi summarize the etiology and pathophysiology of systemic lupus erythematosus with a focus on clinical manifestations (particularly ocular), diagnosis, therapy, and prognosis.

Baglivo E & Ribi C. In: Intraocular inflammation. Edited by Zierhut M et al. Springer-Verlag Berlin Heidelberg, 2016. doi:10.1007/978-3-540-75387-2_68

Exposure to certain external stimuli may act as a trigger for systemic lupus erythematosus (SLE) in genetically susceptible individuals. Relle et al review the possible role of epigenetic alterations in SLE.

Relle M, Foehr B, & Schwarting A. Rheumatol Ther 2015;2:33–46. doi:10.1007/s40744-015-0014-y

Mohan and Putterman discuss genetic insights and molecular mechanisms for the key pathogenic contributors in systemic lupus erythematosus and lupus nephritis.

Nat Rev Nephrol 2015;11:329–341. doi:10.1038/nrneph.2015.33