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10-04-2016 | Systemic lupus erythematosus | Book Chapter | Article

2. Epidemiology of Systemic Lupus Erythematosus

Authors: Simone Baldovino, Cristiana Rollino

Publisher: Springer International Publishing

Abstract

Systemic lupus erythematosus (SLE) is a severe autoimmune rheumatic disease of unclear etiology that affects people worldwide. SLE presents with a wide spectrum of clinical patterns and can affect people of all ages and ethnicities. Regardless of age at disease onset, the diagnosis relies upon a combination of clinical and laboratory findings which are dealt with in greater detail in other sections of the book. According to the most recent revision of the literature, incidence rates of SLE range from approximately 1 to 10 per 100,000 person-years, and prevalence rates generally range from 20 to 70 per 100,000. Even if SLE occurs throughout the world, many variables such as ethnicity, geography, sex, and age affect the epidemiology of SLE. In this chapter we aim to critically review the epidemiology of SLE.

Tsokos GC (2011) Systemic lupus erythematosus. N Engl J Med 365(22):2110–2121. doi:10.1056/NEJMra1100359 CrossRefPubMed

Tan EM, Cohen AS, Fries JF et al (1982) The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 25(11):1271–1277, http://www.ncbi.nlm.nih.gov/pubmed/7138600. Accessed 13 May 2015CrossRefPubMed

Levin RE, Weinstein A, Peterson M et al (1984) A comparison of the sensitivity of the 1971 and 1982 American Rheumatism Association criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 27(5):530–538, http://www.ncbi.nlm.nih.gov/pubmed/6721885. Accessed 13 May 2015CrossRefPubMed

Passas CM, Wong RL, Peterson M et al (1985) A comparison of the specificity of the 1971 and 1982 American Rheumatism Association criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 28(6):620–623, http://www.ncbi.nlm.nih.gov/pubmed/4004972. Accessed 13 May 2015CrossRefPubMed

Petri M (2005) Review of classification criteria for systemic lupus erythematosus. Rheum Dis Clin N Am 31(2):245–254, vi. doi:10.1016/j.rdc.2005.01.009 CrossRef

Petri M, Orbai A-M, Alarcón GS et al (2012) Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum 64(8):2677–2686. doi:10.1002/art.34473 CrossRefPubMedPubMedCentral

Uramoto KM, Michet CJ, Thumboo J et al (1999) Trends in the incidence and mortality of systemic lupus erythematosus, 1950–1992. Arthritis Rheum 42(1):46–50. doi:10.1002/1529-0131(199901)42:1<46::AID-ANR6>3.0.CO;2-2 CrossRefPubMed

Voss A, Green A, Junker P (1998) Systemic lupus erythematosus in Denmark: clinical and epidemiological characterization of a county-based cohort. Scand J Rheumatol 27(2):98–105, http://www.ncbi.nlm.nih.gov/pubmed/9572634. Accessed 23 May 2015CrossRefPubMed

Johnson AE, Gordon C, Hobbs FD et al (1996) Undiagnosed systemic lupus erythematosus in the community. Lancet 347(8998):367–369, http://www.ncbi.nlm.nih.gov/pubmed/8598703. Accessed 23 May 2015CrossRefPubMed

10.

Geva E, Lerner-Geva L, Burke M et al (2004) Undiagnosed systemic lupus erythematosus in a cohort of infertile women. Am J Reprod Immunol 51(5):336–340. doi:10.1111/j.1600-0897.2004.00165.x CrossRefPubMed

11.

Somers EC, Marder W, Cagnoli P et al (2014) Population-based incidence and prevalence of systemic lupus erythematosus: the Michigan Lupus Epidemiology and Surveillance program. Arthritis Rheumatol (Hoboken NJ) 66(2):369–378. doi:10.1002/art.38238 CrossRef

12.

Pons-Estel GJ, Alarcon GS, Scofield L et al (2010) Understanding the epidemiology and progression of systemic lupus erythematosus. Semin Arthritis Rheum 39(4):257–268. doi:10.1016/j.semarthrit.2008.10.007 CrossRefPubMedPubMedCentral

13.

Osio-Salido E, Manapat-Reyes H (2010) Epidemiology of systemic lupus erythematosus in Asia. Lupus 19(12):1365–1373. doi:10.1177/0961203310374305 CrossRefPubMed

14.

Mok CC (2011) Epidemiology and survival of systemic lupus erythematosus in Hong Kong Chinese. Lupus 20(7):767–771. doi:10.1177/0961203310388447 CrossRefPubMed

15.

Barnabe C, Joseph L, Belisle P et al (2012) Prevalence of systemic lupus erythematosus and systemic sclerosis in the First Nations population of Alberta, Canada. Arthritis Care Res (Hoboken) 64(1):138–143. doi:10.1002/acr.20656 CrossRef

16.

Furst DE, Clarke AE, Fernandes AW et al (2013) Incidence and prevalence of adult systemic lupus erythematosus in a large US managed-care population. Lupus 22(1):99–105. doi:10.1177/0961203312463110 CrossRefPubMed

17.

Ng R, Bernatsky S, Rahme E (2013) Observation period effects on estimation of systemic lupus erythematosus incidence and prevalence in Quebec. J Rheumatol 40(8):1334–1336. doi:10.3899/jrheum.121215 CrossRefPubMed

18.

Shim J-S, Sung Y-K, Joo YB et al (2014) Prevalence and incidence of systemic lupus erythematosus in South Korea. Rheumatol Int 34(7):909–917CrossRefPubMed

19.

Lim SS, Bayakly AR, Helmick CG et al (2014) The incidence and prevalence of systemic lupus erythematosus, 2002–2004: the Georgia Lupus Registry. Arthritis Rheumatol (Hoboken NJ) 66(2):357–368. doi:10.1002/art.38239 CrossRef

20.

Zou Y-F, Feng C-C, Zhu J-M et al (2014) Prevalence of systemic lupus erythematosus and risk factors in rural areas of Anhui Province. Rheumatol Int 34(3):347–356. doi:10.1007/s00296-013-2902-1 CrossRefPubMed

21.

Simard JF, Sjowall C, Ronnblom L et al (2014) Systemic lupus erythematosus prevalence in Sweden in 2010: what do national registers say? Arthritis Care Res (Hoboken) 66(11):1710–1717. doi:10.1002/acr.22355 CrossRef

22.

Arnaud L, Fagot J-P, Mathian A et al (2014) Prevalence and incidence of systemic lupus erythematosus in France: a 2010 nation-wide population-based study. Autoimmun Rev 13(11):1082–1089. doi:10.1016/j.autrev.2014.08.034 CrossRefPubMed

23.

Ferucci ED, Johnston JM, Gaddy JR et al (2014) Prevalence and incidence of systemic lupus erythematosus in a population-based registry of American Indian and Alaska Native people, 2007–2009. Arthritis Rheumatol (Hoboken NJ) 66(9):2494–2502. doi:10.1002/art.38720 CrossRef

24.

Rees F, Doherty M, Grainge M et al (2014) The incidence and prevalence of systemic lupus erythematosus in the UK, 1999–2012. Ann Rheum Dis. doi:10.1136/annrheumdis-2014-206334 PubMedPubMedCentral

25.

Nikpour M, Bridge JA, Richter S (2014) A systematic review of prevalence, disease characteristics and management of systemic lupus erythematosus in Australia: identifying areas of unmet need. Intern Med J 44(12a):1170–1179. doi:10.1111/imj.12568 CrossRefPubMed

26.

Ju JH, Yoon S-H, Kang KY et al (2014) Prevalence of systemic lupus erythematosus in South Korea: an administrative database study. J Epidemiol 24(4):295–303CrossRefPubMedPubMedCentral

27.

Nasonov E, Soloviev S, Davidson JE et al (2014) The prevalence and incidence of systemic lupus erythematosus (SLE) in selected cities from three Commonwealth of Independent States countries (the Russian Federation, Ukraine and Kazakhstan). Lupus 23(2):213–219. doi:10.1177/0961203313512881 CrossRefPubMed

28.

Jarukitsopa S, Hoganson DD, Crowson CS et al (2014) Epidemiology of systemic lupus erythematosus and cutaneous lupus in a predominantly white population in the United States. Arthritis Care Res (Hoboken). doi:10.1002/acr.22502

29.

Brinks R, Fischer-Betz R, Sander O et al (2014) Age-specific prevalence of diagnosed systemic lupus erythematosus in Germany 2002 and projection to 2030. Lupus 23(13):1407–1411. doi:10.1177/0961203314540352 CrossRefPubMed

30.

Housey M, DeGuire P, Lyon-Callo S et al (2015) Incidence and prevalence of systemic lupus erythematosus among Arab and Chaldean Americans in southeastern Michigan: the Michigan Lupus Epidemiology and Surveillance Program. Am J Public Health 105(5):e74–e79. doi:10.2105/AJPH.2014.302423 CrossRefPubMed

31.

Urowitz MB, Gladman DD, Tom BDM et al (2008) Changing patterns in mortality and disease outcomes for patients with systemic lupus erythematosus. J Rheumatol 35(11):2152–2158CrossRefPubMed

32.

Ståhl-Hallengren C, Jönsen A, Nived O et al (2000) Incidence studies of systemic lupus erythematosus in Southern Sweden: increasing age, decreasing frequency of renal manifestations and good prognosis. J Rheumatol 27(3):685–691, http://www.ncbi.nlm.nih.gov/pubmed/10743809. Accessed 23 May 2015PubMed

33.

Molina MJ, Mayor AM, Franco AE et al (2007) Prevalence of systemic lupus erythematosus and associated comorbidities in Puerto Rico. J Clin Rheumatol 13(4):202–204. doi:10.1097/RHU.0b013e318124a8af CrossRefPubMedPubMedCentral

34.

Deng Y, Tsao BP (2014) Advances in lupus genetics and epigenetics. Curr Opin Rheumatol 26(5):1–11. doi:10.1097/BOR.0000000000000086 CrossRef

35.

Wang J, Yang S, Chen JJ et al (2007) Systemic lupus erythematosus: a genetic epidemiology study of 695 patients from China. Arch Dermatol Res 298(10):485–491. doi:10.1007/s00403-006-0719-4 CrossRefPubMed

36.

Simard JF, Costenbader KH (2007) What can epidemiology tell us about systemic lupus erythematosus? Int J Clin Pract 61(7):1170–1180. doi:10.1111/j.1742-1241.2007.01434.x CrossRefPubMed

37.

Deng Y, Tsao BP (2011) Genetic susceptibility to systemic lupus erythematosus in the genomic era. Nat Rev Rheumatol 6(12):683–692. doi:10.1038/nrrheum.2010.176.Genetic CrossRef

38.

Kamphuis S, Silverman ED (2010) Prevalence and burden of pediatric-onset systemic lupus erythematosus. Nat Rev Rheumatol 6(9):538–546. doi:10.1038/nrrheum.2010.121 CrossRefPubMed

39.

Arnaud L, Mathian A, Boddaert J et al (2012) Late-onset systemic lupus erythematosus: epidemiology, diagnosis and treatment. Drugs Aging 29(3):181–189. doi:10.2165/11598550-000000000-00000 CrossRefPubMed

40.

Costenbader KH, Kim DJ, Peerzada J et al (2004) Cigarette smoking and the risk of systemic lupus erythematosus: a meta-analysis. Arthritis Rheum 50(3):849–857. doi:10.1002/art.20049 CrossRefPubMed

41.

Mak A, Tay S (2014) Environmental factors, toxicants and systemic lupus erythematosus. Int J Mol Sci 15(9):16043–16056. doi:10.3390/ijms150916043 CrossRefPubMedPubMedCentral

42.

Wang J, Pan H-F, Ye D-Q et al (2008) Moderate alcohol drinking might be protective for systemic lupus erythematosus: a systematic review and meta-analysis. Clin Rheumatol 27(12):1557–1563. doi:10.1007/s10067-008-1004-z CrossRefPubMed

43.

Postal M, Appenzeller S (2011) The role of Tumor Necrosis Factor-alpha (TNF-α) in the pathogenesis of systemic lupus erythematosus. Cytokine 56(3):537–543. doi:10.1016/j.cyto.2011.08.026

44.

McGarvey PB, Suzek BE, Baraniuk JN et al (2014) In silico analysis of autoimmune diseases and genetic relationships to vaccination against infectious diseases. BMC Immunol 15(1):1–12. doi:10.1186/s12865-014-0061-0 CrossRef

45.

Qian G, Ran X, Zhou CX et al (2014) Systemic lupus erythematosus patients in the low-latitude plateau of China: altitudinal influences. Lupus 23(14):1537–1545. doi:10.1177/0961203314544186 CrossRefPubMed

46.

Leffler J, Bengtsson AA, Blom AM (2014) The complement system in systemic lupus erythematosus: an update. Ann Rheum Dis 73(9):1601–1606. doi:10.1136/annrheumdis-2014-205287 CrossRefPubMed

47.

Chen Y-M, Lin C-HC-H, Chen H-H et al (2013) Onset age affects mortality and renal outcome of female systemic lupus erythematosus patients: a nationwide population-based study in Taiwan. Rheumatology 53(1):180–185. doi:10.1093/rheumatology/ket330 CrossRefPubMed

48.

Petri M, Bello KJ, Fang H et al (2013) Vitamin D in systemic lupus erythematosus: modest association with disease activity and the urine protein-to-creatinine ratio. Arthritis Rheum 65(7):1865–1871. doi:10.1002/art.37953 CrossRefPubMedPubMedCentral

49.

Saxena R, Mahajan T, Mohan C (2011) Lupus nephritis: current update. Arthritis Res Ther 13:240–252CrossRefPubMedPubMedCentral

50.

Seligman VA, Lum RF, Olson JL, et al (2002) Demographic differences in the development of lupus nephritis: a retrospective analysis. Am J Med 112:726–729CrossRefPubMed

51.

Mak A, Mok CC, Chu WP et al (2007) Renal damage in systemic lupus erythematosus: a comparative analysis of different age groups. Lupus 16:28–34CrossRefPubMed

52.

Weening JJ, D’Agati VD, Schwartz MM et al (2004) The classification of glomerulonephritis in systemic lupus erythematosus revisited. Am J Kidney Dis 15:241–250

53.

Wakasugi D, Gono T, Kawaguchi Y et al (2012) Frequency of class III and IV nephritis in systemic lupus erythematosus without clinical renal involvement: an analysis of predictive measures. J Rheumatol 39:79CrossRefPubMed

54.

Osler W (1904) On the visceral manifestations of the erythema group of skin diseases. Am J Med Sci 127:1–23CrossRef

55.

Maroz N, Segal MS (2013) Lupus nephritis and end-stage kidney disease. Am J Med Sci 346:319–323CrossRefPubMed

56.

Jarrett M, Santhanam S, Del Greco F (1983) The clinical course of endstage renal disease in systemic lupus erythematosus. Arch Intern Med 143:1353–1356CrossRefPubMed

57.

Cervera R, Khamashta M, Hughes G (2009) The Euro-lupus project: epidemiology of systemic lupus erythematosus in Europe. Lupus 18:869–874CrossRefPubMed

58.

Mojcik C, Klippel J (1996) End-stage renal disease and systemic lupus erythematosus. Am J Med 101:100–107CrossRefPubMed

59.

Ward MM (2009) Changes in the incidence of endstage renal disease due to lupus nephritis in the United States, 1996–2004. J Rheumatol 36:63–67PubMedPubMedCentral

60.

Ward MM (2000) Changes in the incidence of end-stage renal disease due to lupus nephritis, 1982–1995. Arch Intern Med 160:3136–3140CrossRefPubMed

61.

Patel M, Clarke AM, Bruce IN et al (2006) The prevalence and incidence of biopsy-proven lupus nephritis in the UK: evidence of an ethnic gradient. Arthritis Rheum 54:2963–2969

62.

Feldman CH, Hiraki LT, Liu J et al (2013) Epidemiology and sociodemographics of systemic lupus erythematosus and lupus nephritis among U.S. adults with Medicaid coverage, 2000–2004. Arthritis Rheum 65:753–763

63.

Iseki K, Miyasato F, Oura T et al (1994) An epidemiologic analysis of end-stage lupus nephritis. Am J Kidney Dis 23:547–554CrossRefPubMed

64.

Andrade RM, Alarcon GS, Fernandez S et al LUMINA Study Group (2007) Accelerated damage accrual among men with systemic lupus erythematosus: XLIV. Results from a multiethnic US cohort. Arthritis Rheum 56:622–630

65.

Chen HA, Wang JJ, Chou CT et al (2011) Predictors of long term mortality in patients with and without systemic lupus erythematosus on maintenance dialysis: a comparative study. J Rheumatol 38:2390–2394CrossRefPubMed

66.

McCarty DJ, Manzi S, Medsger TA Jr et al (1995) Incidence of systemic lupus erythematosus: race and gender differences. Arthritis Rheum 38:1260–1270

67.

Bastian HM, Roseman JM, McGwin G Jr et al (2002) Systemic lupus erythematosus in three ethnic groups. XII. Risk factors for lupus nephritis after diagnosis. Lupus 11:152–160CrossRefPubMed

68.

Costenbader K, Desai A, Alarcon G et al (2011) Trends in the incidence, demographics, and outcomes of end-stage renal disease due to lupusnephritis in the US from 1995 to 2006. Arthritis Rheum 63:1681–1688CrossRefPubMedPubMedCentral

69.

Hiraki L, Lu B, Alexander S et al (2011) End-stage renal disease due to lupus nephritis among children in the US, 1995–2006. Arthritis Rheum 63:1988–1997CrossRefPubMedPubMedCentral

70.

Bartosh SM, Fine RN, Sullivan EK (2001) Outcome after transplantation of young patients with systemic lupus erythematosus: a report of the North American pediatric renal transplant cooperative study. Transplantation 72:973–978CrossRefPubMed

71.

Fiehn C, Hajjar Y, Mueller K et al (2003) Improved clinical outcome of lupus nephritis during the past decade: importance of early diagnosis and treatment. Ann Rheum Dis 62:435–439CrossRefPubMedPubMedCentral

72.

Esdaile J, Levinton C, Federgreen W et al (1989) The clinical and renal biopsy predictors of long-term outcome in lupus nephritis: a study of 87 patients and review of the literature. Q J Med 72:779–833PubMed

73.

Sexton DJ, Reule S, Solid C et al (2015) ESKD from lupus nephritis in the United States, 1995–2010. Clin J Am Soc Nephrol 10:251–259CrossRefPubMedPubMedCentral

74.

Brentjens JR, Sepulveda M, Baliah T et al (1975) Interstitial immune complex nephritis in patients with systemic lupus erythematosus. Kidney Int 7:342CrossRefPubMed

75.

Park MH, D’Agati V, Appel GB et al (1986) Tubulointerstitial disease in lupus nephritis: relationship to immune deposits, interstitial inflammation, glomerular changes, renal function, and prognosis. Nephron 44:309CrossRefPubMed

76.

Yu F, Wu LH, Tan Y et al (2010) Tubulointerstitial lesions of patients with lupus nephritis classified by the 2003 International Society of Nephrology and Renal Pathology Society system. Kidney Int 77:820CrossRefPubMed

77.

Kozeny GA, Barr W, Bansal VK et al (1987) Occurrence of renal tubular dysfunction in lupus nephritis. Arch Intern Med 147:891CrossRefPubMed

78.

DeFronzo RA, Cooke CR, Goldberg M et al (1977) Impaired renal tubular potassium secretion in systemic lupus erythematosus. Ann Intern Med 86:268CrossRefPubMed

79.

Wu LH, Yu F, Tan Y et al (2013) Inclusion of renal vascular lesions in the 2003 ISN/RPS system for classifying lupus nephritis improves renal outcome predictions. Kidney Int 83:715CrossRefPubMed

80.

Kwok SK, Ju JH, Cho CS et al (2009) Thrombotic thrombocytopenic purpura in systemic lupus erythematosus: risk factors and clinical outcome: a single centre study. Lupus 18:16CrossRefPubMed

81.

Song D, Wu LH, Wang FM et al (2013) The spectrum of renal thrombotic microangiopathy in lupus nephritis. Arthritis Res Ther 15:R12CrossRefPubMedPubMedCentral

82.

Abdellatif AA, Waris S, Lakhani A et al (2010) True vasculitis in lupus nephritis. Clin Nephrol 74:106CrossRefPubMed

83.

Gelfand J, Truong L, Stern L et al (1985) Thrombotic thrombocytopenic purpura syndrome in systemic lupus erythematosus: treatment with plasma infusion. Am J Kidney Dis 6:154CrossRefPubMed

Medicine Matters Rheumatology

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