Osteoarthritis

Treatment with the IL-1β inhibitor canakinumab is associated with a reduced incidence of total joint replacement, suggests an exploratory analysis of the CANTOS trial.

Placebo, followed by telephone-based cognitive behavioral therapy, does not meet noninferiority criteria compared with meloxicam for pain relief in patients with knee osteoarthritis, say US researchers.

Wearing individually calibrated biomechanical footwear for 24 weeks results in a statistically significant reduction in knee pain among people with osteoarthritis, suggest results from the BIOTOK trial published in JAMA.

Annual infusions of zoledronic acid do not reduce cartilage volume loss, pain, or bone marrow lesion size in people with knee osteoarthritis, suggest findings from the phase 3 ZAP2 trial.

People with symptomatic knee osteoarthritis who undergo physical therapy have greater reductions in pain and functional disability over 1 year than those given intra-articular glucocorticoid injections, randomized trial results suggest.

Sprifermin, also known as recombinant human fibroblast growth factor 18, increases cartilage thickness and reduces cartilage loss in patients with knee osteoarthritis independent of location in the femorotibial joint, shows a post-hoc analysis of the FORWARD study.

Sharon Kolasinski talks about what’s new in the latest ACR–Arthritis Foundation recommendations for the management of osteoarthritis, and highlights the key take-home messages for healthcare providers.

Updated evidence-based guidelines for the management of hand, hip, and knee osteoarthritis in the USA have been issued by the ACR and the Arthritis Foundation.

Phase 2a trial results suggest the cathepsin K inhibitor MIV-711 warrants further investigation as a disease-modifying drug for osteoarthritis.

Nathan Foulquier and Alain Saraux evaluate the use of machine learning for the classification and diagnosis of rheumatic diseases.

Dislocation risk following total hip replacement is declining with time and is associated with a number of surgical, hospital, and patient-related factors that are generally modifiable, UK researchers report.

People with osteoarthritis have a significantly higher risk for developing cardiovascular disease than those without, and the use of nonsteroidal anti-inflammatory drugs mediates a considerable proportion of this association, researchers report.

Partial knee replacement is more cost-effective than total knee replacement over 5 years for patients with late-stage isolated medial compartment osteoarthritis of the knee, show results of the TOPKAT trial published in The Lancet.

Clinic-based or inpatient rehabilitation programs are not superior to home-based programs for individuals who undergo total knee replacement without complications, suggests a systematic review and meta-analysis.

A panel of four soluble biomarkers comprising markers of cartilage metabolism, metabolic syndrome, and inflammation could distinguish psoriatic arthritis from osteoarthritis, researchers report.

Mortality rates are significantly higher during the first year after a tramadol prescription than after prescription of common nonsteroidal anti-inflammatory drugs, but it is unclear whether the relationship is causal, say researchers.

Editorial board member Oliver FitzGerald presents a family with two siblings having features consistent with angel-shaped phalango-epiphyseal dysplasia (ASPED), and a mother with a normal phenotype but with severe, early-onset multi-joint osteoarthritis.

Two meta-analyses published in The Lancet provide estimates for how long hip and knee replacements are likely to last in patients with osteoarthritis.

Patients who are treated with ibuprofen alone experience comparable pain control in the first day after hip replacement to those give acetaminophen plus ibuprofen, findings from the PANSAID trial suggest.

Findings from a systematic review and network meta-analysis published in JAMA indicate that it is not clear whether pharmacologic treatments offer long-term benefits for patients with knee osteoarthritis.