Risk prediction

The authors explore the hypothesis that early life experiences may induce stress reactions and other responses that modify DNA methylation patterns and consequently influence the risk of osteoporosis in later life.

Riancho JA, Brennan-Olsen SL. Clinic Rev Bone Miner Metab 2017;15:59-68. doi:10.1007/s12018-017-9229-5

The authors provide an overview of transient osteoporosis of the hip, covering the epidemiology, pathophysiology, etiology, diagnosis, treatment, and potential complications of the condition.1

Asadipooya K, Graves L, Greene LW. Osteoporos Int 2017;28:1805–1816. doi:10.1007/s00198-017-3952-0

In this chapter, the authors review the importance of genetic risk factors for the development of generalized osteoporosis and in relation to fracture rates in the elderly.

Karasik D, Kiel DP. In: Osteoporosis in Older Persons. Edited by Duque G, Kile DP. Springer International Publishing Switzerland, 2016. doi:10.1007/978-3-319-25976-5_8

This chapter explores the epidemiology of osteoporosis and fragility fracture, cell biology and biomechanics, and the latest research on global trends in age- and sex-specific fracture rates.

Moon RJ, Cooper C, Harvey NC. In: The Duration and Safety of Osteoporosis Treatment. Edited by Silverman S, Abrahamsen B. Springer International Publishing Switzerland, 2016. doi:10.1007/978-3-319-23639-1_1

This review discusses the main heritable and non-heritable factors that contribute to the pathogenesis of primary osteoporosis, focusing on the genetic and epigenetic basis of polygenic osteoporosis.

Nat Rev Rheumatol 2015;11:462–474. doi:10.1038/nrrheum.2015.48

In this article, Gong et al provide an expert review of the new technologies for fracture risk prediction, diagnosis, and treatment of postmenopausal osteoporosis.

Gong B et al. Curr Osteoporos Rep 2014;12:357–365. doi:10.1007/s11914-014-0215-2