Pathophysiology

Radovanović-Dinić B et al. Rheumatol Int 2018; Advance online publication. doi: 10.1007/s00296-018-4021-5

Wampler TL, Niewold TB. Nat Rev Rheumatol 2018; 14: 214–228. doi: 10.1038/nrrheum.2018.31

Mizoguchi F et al. Nat Commun 2018; 9: 789. doi: 10.1038/s41467-018-02892-y

Kohno Y et al. BMC Musculoskelet Disord 2018; 19: 78. doi: 10.1186/s12891-018-1998-6

Bodis G, Toth V, Schwarting A. Rheumatol Ther 2018; Advance online publication. doi: 10.1007/s40744-018-0100-z

Hähnlein JS et al. Arthritis Res Ther 2018; 20: 35. doi: 10.1186/s13075-018-1529-8

Plutzky J, Liao KP. Curr Rheumatol Rep 2018; 20: 8. doi: 10.1007/s11926-018-0715-7

Qian J et al. Arthritis Res Ther 2018; 20: 26. doi: 10.1186/s13075-018-1526-y

Nat Rev Rheumatol 2018; 14: 170–180. doi: 10.1038/nrrheum.2018.17

Barturen G et al. Nat Rev Rheumatol 2018; 14: 75–93. doi: 10.1038/nrrheum.2017.220

In this review, the authors discuss three interconnected mechanisms that might be involved in the predilection of specific joints for developing specific forms of arthritis.

Nat Rev Rheumatol 2017;13:433–442. doi:10.1038/nrrheum.2017.96

In this review, Weyand & Goronzy examine emerging data on metabolism in immune cells in seropositive rheumatoid arthritis and look at how metabolic programs affect the disease process.

Nat Rev Rheumatol 2017;13:291–301. doi:10.1038/nrrheum.2017.49

The authors use RNA-sequence data and integrate the results with association studies, to consequently implicate new candidate genes in the pathogenesis of rheumatoid arthritis.

Shchetynsky K et al. Arthritis Res Ther 2017;19:19. doi:10.1186/s13075-017-1220-5

This review summarizes potential pathways involved in how systemic autoimmunity progresses to joint-specific inflammation, focusing particularly on osteoclasts as the primary targets. 

Nat Rev Rheumatol 2017;13:79–86. doi:10.1038/nrrheum.2016.200

In this review, recent progress in understanding disease development in seropositive rheumatoid arthritis patients is summarized, and implications for therapeutic strategies are emphasized. 

Nat Rev Immunol 2017;17:60–75. doi:10.1038/nri.2016.124

This review looks at current knowledge on the role of extracellular vesicles in rheumatoid arthritis and osteoarthritis, and their potential role as therapeutic targets. 

Withrow J et al. Arthritis Res Ther 2016;18:286. doi:10.1186/s13075-016-1178-8

A summary of the genetic loci associated with susceptibility to rheumatoid arthritis, the latest insights from genetic studies, and how this data have helped to identify alternative treatment options. 

Nat Rev Rheumatol 2017;13:13–24. doi:10.1038/nrrheum.2016.176

This study explores the relationship of GlycA with inflammation and cardiometabolic risk in rheumatoid arthritis, showing that GlycA provides an integrated measure of inflammation.

Bartlett DB et al. Arthritis Res Ther 2016;18:86. doi:10.1186/s13075-016-0982-5

Ceribelli A et al. Clinic Rev Allerg Immunol 2017; 52: 58–70. doi: 10.1007/s12016-016-8527-x