Pathophysiology

Zhou H et al. Clin Rheumatol 2018. doi: 10.1007/s10067-018-4124-0

Batu ED. Rheumatol Int 2018. doi: 10.1007/s00296-018-4048-7

Zhang H et al. Arthritis Res Ther 2018; 20: 92. doi: 10.1186/s13075-018-1590-3

Miller FW et al. Nat Rev Rheumatol 2018; 14: 255–268. doi: 10.1038/nrrheum.2018.48

McHugh NJ, Tansley SL. Nat Rev Rheumatol 2018; 14: 290–302. doi: 10.1038/nrrheum.2018.56

Miao J & Zhu P. Curr Rheumatol Rep 2018; 20(5): 30. doi: 10.1007/s11926-018-0729-1

Lundberg IE, de Visser M, Werth VP. Nat Rev Rheumatol 2018; 14: 269–278. doi: 10.1038/nrrheum.2018.41

Commensal bacteria may be involved in triggering systemic lupus erythematosus in genetically predisposed individuals, results of a proof-of-concept study suggest.

Wampler TL, Niewold TB. Nat Rev Rheumatol 2018; 14: 214–228. doi: 10.1038/nrrheum.2018.31

La Cava A. Curr Rheumatol Rep 2018; 20: 6. doi: 10.1007/s11926-018-0714-8

Deng GM. Curr Rheumatol Rep 2018; 20: 5. doi: 10.1007/s11926-018-0713-9

Barturen G et al. Nat Rev Rheumatol 2018; 14: 75–93. doi: 10.1038/nrrheum.2017.220

In this study, the authors confirm a strong involvement of B cells in the pathogenesis of systemic lupus erythematosus.

Almlöf JC, Alexsson A, Imgenberg-Kreuz J et al. Scientific Reports 2017;7:6236. doi:10.1038/s41598-017-06516-1

In this study, Langefeld et al. discover that systemic lupus erythematosus has a strong genetic contribution to risk with ancestry-dependent and ancestry-independent contributions.

Nat Commun 2017;8:16021. doi:10.1038/ncomms16021

In this review, the authors discuss three interconnected mechanisms that might be involved in the predilection of specific joints for developing specific forms of arthritis.

Nat Rev Rheumatol 2017;13:433–442. doi:10.1038/nrrheum.2017.96

The framework for understanding systemic lupus erythematosus (SLE) has remained the same for the last decade. Tsokos et al. review new insights that offer the potential for novel interventions in SLE.

Nat Rev Rheumatol 2016;12:716–730. doi:10.1038/nrrheum.2016.186

Fujimoto M et al. Curr Opin Rheumatol 2016; 28: 636–644. doi: 10.1097/BOR.0000000000000329

Rider LG, Nistala K. J Intern Med 2016; 280: 24–38. doi: 10.1111/joim.12444

Systemic lupus erythematosus is characterized by flares that punctuate the course of this chronic disease. In this review, Fernandez and Kirou discuss evidence for environmental triggers of disease flares.

Fernandez D & Kirou KA. Curr Rheumatol Rep 2016;18:14. doi:10.1007/s11926-016-0562-3

Ceribelli A et al. Clinic Rev Allerg Immunol 2017; 52: 58–70. doi: 10.1007/s12016-016-8527-x