Pediatric rheumatology

The author discusses sexual function and fertility in rheumatic disease, suggesting that successful management should include regular family planning, effective treatment, sexual counseling, and infertility treatment.

Nat Rev Rheumatol 2017;13:485–493. doi:10.1038/nrrheum.2017.102

The authors review the published data about methotrexate-induced nausea in the treatment of juvenile idiopathic arthritis, as well as possible management approaches including the use of newer antinausea medications.

Falvey S, Shipman L, Ilowite N, Beukelman T. Pediatr Rheumatol 2017;15:52. doi:10.1186/s12969-017-0180-2

Kellett et al. summarize the recent literature on the pathogenesis, management, and outcome of small-, medium-, and large-vessel renal vasculitis in the pediatric population.

Kellett S, Jawa N, Noone D. Curr Pediatr Rep 2017;5:87-99. doi:10.1007/s40124-017-0138-3

In this review, the authors summarize recent literature addressing the risk factors, evaluation, and treatment for early bone fragility in patients with osteoporosis.

Grover M, Bachrach LK. Curr Osteoporos Rep 2017;15:271–282. doi:10.1007/s11914-017-0371-2

Coda et al. describe how by embracing and adapting new and highly-accessible interactive technologies, clinical management and research of juvenile idiopathic arthritis may be greatly advanced.

Coda A, Sculley D, Santos D et al. Pediatr Rheumatol 2017;15:40. doi:10.1186/s12969-017-0168-y

The findings of this study suggest a possible role for the lectin pathway in the pathogenesis of juvenile idiopathic arthritis, perhaps secondary to a role in host defense.

Immunol Cell Biol 2017;95:666-675. doi:10.1038/icb.2017.31

Oral ulcers are the most common mucosal sign in juvenile-onset systemic lupus erythematosus (JSLE). This article reviews the clinical manifestations, diagnosis, and management of oral ulcers in patients with JSLE.

Rodsaward P, Prueksrisakul T, Deekajorndech T et al. Am J Clin Dermatol 2017. doi:10.1007/s40257-017-0286-9

This study finds that ultrasound-guided tendon sheath injections, a frequently performed procedure in patients with juvenile idiopathic arthritis, are a safe intervention with a high technical success rate.

Peters SE, Laxer RM, Connolly BL, Parra DA. Pediatr Rheumatol 2017;15:22. doi:10.1186/s12969-017-0155-3

Osteoporosis is increasingly recognized in children due to the increased prevalence of disorders associated with bone loss. This review explores diagnosis and treatment considerations in this population.

Marrani E et al. Drugs 2017;77:679–695. doi:10.1007/s40265-017-0715-3

An evidence-based update on insights into the healthy sonoanatomy of children and the use of ultrasound in the assessment and treatment of juvenile idiopathic arthritis disease manifestations.

Oberle EJ. Curr Treat Options in Rheum 2017;3:49. doi:10.1007/s40674-017-0060-4

Malattia and Martini provide a comprehensive overview of juvenile idiopathic arthritis by discussing the etiopathogeneis, clinical presentation, and classification of this disease.

Malattia C, Martini A. In: Pediatric Rheumatology. Edited by Sawhney S, Aggarwal A.  Springer Science+Business Media Singapore, 2017. doi:10.1007/978-981-10-1750-6_17

In this chapter, the author provides an overview of the epidemiology of pediatric rheumatic diseases focusing primarily on juvenile idiopathic arthritis, which is the most common pediatric disease.

Manners PJ. In: Pediatric Rheumatology. Edited by Sawhney S, Aggarwal A.  Springer Science+Business Media Singapore, 2017. doi:10.1007/978-981-10-1750-6_5

A case report reviewing two siblings with severe familial forms of juvenile idiopathic arthritis (JIA) and the causal role of mutations in FAMIN for this and other form of JIA.

Kallinich T et al. Pediatr Rheumatol 2016;14:63. doi:10.1186/s12969-016-0124-2

This review aims to provide an update on the use of imaging in the assessment of juvenile spondyloarthritis disease manifestations.

Weiss PF, Chauvin NA, & Roth J. Curr Rheumatol Rep 2016;18:75. doi:10.1007/s11926-016-0624-6

This study used fecal water metabolomics to identify mechanisms by which the altered microbiota in children with enthesitis-related arthritis might contribute to the pathogenesis of this disease.

Genes Immun 2016;17:400–405. doi:10.1038/gene.2016.38

Childhood-onset systemic lupus erythematosus (SLE) requires a multidisciplinary approach due to the complexity of the disease. The authors review recommendations for the management of children with SLE.

Thakral A & Klein-Gitelman MS. Rheumatol Ther 2016;3:209–219. doi:10.1007/s40744-016-0044-0

This study used claims data to compare rates of hospitalized infection among children with juvenile idiopathic arthritis initiating treatment with a biologic agent versus initiating methotrexate treatment.

Beukelmam T, Xie F, Baddley JW, et al. Arthritis Res Ther 2016;18:210. doi:10.1186/s13075-016-1109-8

An expert review of the involvement of the microbiome in juvenile idiopathic arthritis (JIA) pathogenesis and how it may influence the development of autoimmunity in JIA.

Verwoerd A et al. Pediatr Rheumatol 2016;14:55. doi:10.1186/s12969-016-0114-4

This review examines the relationship between the microbiome and pathogenesis in juvenile idiopathic arthritis (JIA), with a focus on potential microbiome-associated mechanisms of disease development.

Verwoerd A, Ter Haar NM, de Roock S, Vastert SJ, Bogaert D. Pediatr Rheumatol. 2016;14:55. doi:10.1186/s12969-016-0114-4

An expert review of the various subtypes of juvenile idiopathic arthritis including the epidemiology, etiology, and clinical manifestations of each subtype.

Laxer RM, Sherry DD, Hashkes PJ. In: Pediatric Rheumatology in Clinical Practice. Edited by Laxer RM, Sherry DD, Hashkes PJ.  Springer-Verlag London, 2016. doi:10.1007/978-3-319-13099-6_3