Pathophysiology

Lee MC et al. Arthritis Res Ther 2018; 20: 62. doi: 10.1186/s13075-018-1560-9

Kohno Y et al. BMC Musculoskelet Disord 2018; 19: 78. doi: 10.1186/s12891-018-1998-6

Conway R, McCarthy GM. Curr Rheumatol Rep 2018; 20: 13. doi: 10.1007/s11926-018-0721-9

Tian H. J Orthop Surg Res 2018; 13: 49. doi: 10.1186/s13018-018-0734-0

Syx D et al. Curr Rheumatol Rep 2018; 20: 9. doi: 10.1007/s11926-018-0716-6

Nat Rev Rheumatol 2018; 14: 170–180. doi: 10.1038/nrrheum.2018.17

Ren G et al. BMC Musculoskelet Disord 2018; 19: 39. doi: 10.1186/s12891-018-1955-4

Barturen G et al. Nat Rev Rheumatol 2018; 14: 75–93. doi: 10.1038/nrrheum.2017.220

In this study, the authors identify consistent molecular players in osteoarthritis progression, that replicated across independent datasets and that have translational potential.

Steinberg J, Ritchie GRS, Roumeliotis TI et al. Scientific Reports 2017;7:8935. doi:10.1038/s41598-017-09335-6

In this review, the authors discuss three interconnected mechanisms that might be involved in the predilection of specific joints for developing specific forms of arthritis.

Nat Rev Rheumatol 2017;13:433–442. doi:10.1038/nrrheum.2017.96

The authors review studies focusing on two multi-functional signaling pathways, discussing the roles of these signaling pathways in osteoarthritis pathophysiology and articular cartilage homeostasis.

Saito T, Tanaka S. Arthritis Res Ther 2017;19:94. doi:10.1186/s13075-017-1296-y

This review introduces basic concepts in epigenetics and their recent applications to the study of osteoarthritis development and progression.

Simon TC, Jeffries MA. Curr Rheumatol Rep 2017;19:30. doi:10.1007/s11926-017-0661-9

In this review, the authors highlight the major developments and potential emerging treatments with the focus on Wnt signaling pathway in osteoarthritis during the last 5 years.

Lane NE, Corr M, Baer N, Yazici Y. Curr Treat Options in Rheum 2017;3:101–111. doi:10.1007/s40674-017-0065-z

This review focusses on aberrant metabolism in the pathogenesis of osteoarthritis, summarizing the current state of knowledge on the role of impaired metabolism in the cells of the osteoarthritic joint.

Nat Rev Rheumatol 2017;13:302–311. doi:10.1038/nrrheum.2017.50

This study determined that adults who develop accelerated knee osteoarthritis (KOA) have greater knee symptoms with certain activities than those with or without incident common KOA.

Davis J et al. Clin Rheumatol 2017;36:1083–1089. doi:10.1007/s10067-017-3564-2

This article reviews knowledge on the prevalence of synovitis in osteoarthritis and its role in symptoms and structural progression, and explores lessons learnt from targeting synovitis therapeutically.

Mathiessen A & Conaghan PG. Arthritis Res Ther 2017;19:18. doi:10.1186/s13075-017-1229-9

Krann discusses how transforming growth factor-β counteracts pathological changes in a young healthy joint, alters its signalling during ageing, and is a driving force of pathology in osteoarthritic joints.

Nat Rev Rheumatol 2017;13:155–163. doi:10.1038/nrrheum.2016.219

Malfait et al. discuss the emerging targets in the preclinical and clinical arena such as nerve growth factor, ion channels, and G-protein coupled receptors for pain management in osteoarthritis.

Malfait AM & Miller RJ. Curr Osteoporos Rep 2016;14:260. doi:10.1007/s11914-016-0326-z

This review provides an overview of possible biochemical, mechanical, and immunological relationships between gout and osteoarthritis, and the implications of these relationships for treatment.

Yokose C et al. Curr Rheumatol Rep 2016;18:65. doi:10.1007/s11926-016-0613-9

The authors examine emerging evidence for a critical role of low-grade inflammation in the pathogenesis of osteoarthritis, and discuss current understanding of the underlying molecular mechanisms.

Nat Rev Rheumatol 2016;12:580–592. doi:10.1038/nrrheum.2016.136