Gout

Tseng CC et al. Arthritis Res Ther 2018; 20: 137. doi: 10.1186/s13075-018-1637-5

Hutton J et al. Arthritis Res Ther 2018; 20: 135. doi: 10.1186/s13075-018-1629-5

Deuteraiou K et al. Rheumatol Int 2018. doi: 10.1007/s00296-018-4074-5

Dobson GP et al. Osteoarthritis Cartilage 2018. doi: 10.1016/j.joca.2018.04.018

Major TJ et al. Nat Rev Rheumatol 2018; Advance online publication. doi: 10.1038/s41584-018-0004-x

Wampler TL, Niewold TB. Nat Rev Rheumatol 2018; 14: 214–228. doi: 10.1038/nrrheum.2018.31

The authors review the current knowledge generated by genome-wide association studies, and discuss the translation of these findings into integrated personalized medicine approaches for hyperuricemia and gout.

Dalbeth N, Stamp LK, Merriman TR. BMC Med 2017;15:108. doi:10.1186/s12916-017-0878-5

In this review, the authors discuss three interconnected mechanisms that might be involved in the predilection of specific joints for developing specific forms of arthritis.

Nat Rev Rheumatol 2017;13:433–442. doi:10.1038/nrrheum.2017.96

This review provides an overview of possible biochemical, mechanical, and immunological relationships between gout and osteoarthritis, and the implications of these relationships for treatment.

Yokose C et al. Curr Rheumatol Rep 2016;18:65. doi:10.1007/s11926-016-0613-9

This paper provides an overview of the ways in which urate is handled by the human body, in terms of production, renal elimination and intestinal elimination.

Hyndman D, Liu S, Miner JN. Curr Rheumatol Rep. 2016;18:34. doi: 10.1007/s11926-016-0587-7.

This systematic literature review was conducted to identify factors contributing to monosodium urate (MSU) crystallization in gout.

Chhana A, Lee G, Dalbeth N. BMC Musculoskel Disord. 2015;16:296. doi: 10.1186/s12891-015-0762-4.

This analysis supports the concept of gout as a persistent crystal deposition disease and suggests new research pathways that might promote initial crystal nucleation and growth on fibres after damage or alteration.

Nat Rev Rheumatol 2015;11:725–730. doi:10.1038/nrrheum.2015.125

This chapter provides an overview of gout, in terms of genetics, mechanisms of disease, and the inflammation and joint damage that occurs, as well as a discussion of the association between the chronic inflammation in gout and cardiovascular outcomes.

Managing gout in primary care. Springer Healthcare, London. 2014:13–24. doi: 10.1007/978-1-907673-67-2.

Genome-wide association studies have identified several new and common genetic factors that contribute to hyperuricemia and gout. This review examines the role of genetics in the development of gout.

George RL & Keenan RT. Curr Rheumatol Rep 2013;15:309. doi:10.1007/s11926-012-0309-8