Systemic lupus erythematosus

Ma K et al. Ann Rheum Dis 2018. doi: 10.1136/annrheumdis-2018-213615

Katz-Talmor D et al. Nat Rev Rheumatol 2018. doi: 10.1038/s41584-018-0025-5

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La Cava A. Curr Rheumatol Rep 2018; 20: 6. doi: 10.1007/s11926-018-0714-8

Wampler TL, Niewold TB. Nat Rev Rheumatol 2018; 14: 214–228. doi: 10.1038/nrrheum.2018.31

Barturen G et al. Nat Rev Rheumatol 2018; 14: 75–93. doi: 10.1038/nrrheum.2017.220

In this study, the authors confirm a strong involvement of B cells in the pathogenesis of systemic lupus erythematosus.

Almlöf JC, Alexsson A, Imgenberg-Kreuz J et al. Scientific Reports 2017;7:6236. doi:10.1038/s41598-017-06516-1

In this review, the authors discuss three interconnected mechanisms that might be involved in the predilection of specific joints for developing specific forms of arthritis.

Nat Rev Rheumatol 2017;13:433–442. doi:10.1038/nrrheum.2017.96

In this study, Langefeld et al. discover that systemic lupus erythematosus has a strong genetic contribution to risk with ancestry-dependent and ancestry-independent contributions.

Nat Commun 2017;8:16021. doi:10.1038/ncomms16021

The framework for understanding systemic lupus erythematosus (SLE) has remained the same for the last decade. Tsokos et al. review new insights that offer the potential for novel interventions in SLE.

Nat Rev Rheumatol 2016;12:716–730. doi:10.1038/nrrheum.2016.186

Systemic lupus erythematosus is characterized by flares that punctuate the course of this chronic disease. In this review, Fernandez and Kirou discuss evidence for environmental triggers of disease flares.

Fernandez D & Kirou KA. Curr Rheumatol Rep 2016;18:14. doi:10.1007/s11926-016-0562-3

Baglivo and Ribi summarize the etiology and pathophysiology of systemic lupus erythematosus with a focus on clinical manifestations (particularly ocular), diagnosis, therapy, and prognosis.

Baglivo E & Ribi C. In: Intraocular inflammation. Edited by Zierhut M et al. Springer-Verlag Berlin Heidelberg, 2016. doi:10.1007/978-3-540-75387-2_68

Exposure to certain external stimuli may act as a trigger for systemic lupus erythematosus (SLE) in genetically susceptible individuals. Relle et al review the possible role of epigenetic alterations in SLE.

Relle M, Foehr B, & Schwarting A. Rheumatol Ther 2015;2:33–46. doi:10.1007/s40744-015-0014-y